Forty-six different species collected in the Mosetene ethnia, dwelling in the Andean Piedmont of Bolivia, were screened for antimalarial properties. Thirty-three extracts were screened for antimalarial activity in vitro on Plasmodium falciparum chloroquine resistant strain (Indo), and forty-seven extracts were evaluated in vivo on the rodent malaria P. vinckei petteri 279BY. Only two plants are specifically used in combination by the Mosetene against malaria attack (Hymenachne donacifolia and Tesseria integrifolia), but they did not display any activity in vivo at 1000 mg/kg. The in vivo most active extracts were Swietenia macrophylla bark, Trema micrantha bark and Triplaris americana bark, not all of them were used for antimalarial purposes by the Mosetene. The following extracts were moderately active: Jacaratia digitata inner bark and Momordica charantia aerial part (both traditionally used as febrifuge), Kalanchoe pinnate aerial part (used in inflammatory processes), Lunania parviflora twigs and leaves, Phyllanthus acuminatus (used as piscicide), Iynanthus schumannianus fruit (used against diarrhoea), Triumfetta semitrilobata (used as febrifuge, to alleviate kidney and gynecological pain) and finally Solanum mammosum fruit (used against scabies). We present here the results of this screening, emphazing on the in vivo antimalarial activity of the selected plants. The antimalarial in vivo activity of the selected species, in relation with their traditional Mosetene use is then discussed. Copyright (C) 2000 Elsevier Science Ireland Ltd.
Nota bibliográficaFunding Information:
The project was financed by FONAMA-EIA Fondo Nacional para el Medio Ambiente, Cuenta Iniciativa para las Americas, Bolivia), IRD (I’institut de Recherche pour le Développement, France), UMSA (Universidad Mayor de San Andrés, La Paz, Bolivia), IBBA (Instituto Boliviano de Biologia Andina, La Paz, Bolivia), the Ministry of French Foreign Affairs, and IFS (International Foundation for Sciences). The authors wish to thank Dr B. Weniger for kindly help in the bibliographical search, and Rosy Chávez de Michel and the National Herbarium of Bolivia for helping in the management and determination of vouchers. We express our thanks to the members of the Mostene communities who were willing to share with us their knowledge of plants.