Screening of South American plants against human immunodeficiency virus: Preliminary fractionation of aqueous extract from Baccharis trinervis

Sonsoles Sanchez Palomino, María José Abad, Luis Miguel Bedoya, Javier García, Eduardo Gonzales, Ximena Chiriboga, Paulina Bermejo, José Alcami

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

28 Citas (Scopus)

Resumen

Ethanolic and aqueous extracts of 14 South American medicinal plants were tested for inhibitory activity on human immunodeficiency virus (HIV). Both extracts were relatively non-toxic to human lymphocytic MT-2 cells, but only the aqueous extract of Baccharis trinervis exhibited potent anti-HIV activity in an in vitro MTT assay. To delineate the extract-sensitive phase, some studies of the antiviral properties of the active extract are described in this paper. Based on the results presented here, a separation scheme was devised, which permitted the preliminary fractionation of the extract, with the aim of finding an inhibitor of this virus.

Idioma originalInglés
Páginas (desde-hasta)1147-1150
Número de páginas4
PublicaciónBiological and Pharmaceutical Bulletin
Volumen25
N.º9
DOI
EstadoPublicada - sep. 2002

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