Preparation and antimalarial activity of semisynthetic lycorenine derivatives

Juan C. Cedrón, David Gutiérrez, Esther Ninoska Flores Quisbert Flores Quisbert, Ángel G. Ravelo, Ana Estévez-Braun

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

12 Citas (Scopus)

Resumen

A set of twenty one lycorenine derivatives has been prepared from the alkaloid hippeastrine (1). The modifications performed on hippeastrine included some functional group transformations, structural simplification and preparation of dimers. All alkaloids were tested as potential antimalarial agents, being the hippeastrine dimers the most active compounds.

Idioma originalInglés
Páginas (desde-hasta)722-730
Número de páginas9
PublicaciónEuropean Journal of Medicinal Chemistry
Volumen63
DOI
EstadoPublicada - 2013

Nota bibliográfica

Funding Information:
This work has been partly funded by the Spanish MEC ( SAF 2009-13296-C02-01 ) and by the ICIC (Instituto Canario de Investigación del Cáncer).

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