Preparation and antimalarial activity of semisynthetic lycorenine derivatives

Juan C. Cedrón; David Gutiérrez; Esther Ninoska Flores Quisbert Flores Quisbert; Ángel G. Ravelo; Ana Estévez-Braun

doi:10.1016/j.ejmech.2013.03.018

Preparation and antimalarial activity of semisynthetic lycorenine derivatives

Juan C. Cedrón, David Gutiérrez, Esther Ninoska Flores Quisbert Flores Quisbert, Ángel G. Ravelo, Ana Estévez-Braun

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

12 Citas (Scopus)

Resumen

A set of twenty one lycorenine derivatives has been prepared from the alkaloid hippeastrine (1). The modifications performed on hippeastrine included some functional group transformations, structural simplification and preparation of dimers. All alkaloids were tested as potential antimalarial agents, being the hippeastrine dimers the most active compounds.

Idioma original	Inglés
Páginas (desde-hasta)	722-730
Número de páginas	9
Publicación	European Journal of Medicinal Chemistry
Volumen	63
DOI	https://doi.org/10.1016/j.ejmech.2013.03.018
Estado	Publicada - 2013

Nota bibliográfica

Funding Information:
This work has been partly funded by the Spanish MEC ( SAF 2009-13296-C02-01 ) and by the ICIC (Instituto Canario de Investigación del Cáncer).

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10.1016/j.ejmech.2013.03.018

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title = "Preparation and antimalarial activity of semisynthetic lycorenine derivatives",

abstract = "A set of twenty one lycorenine derivatives has been prepared from the alkaloid hippeastrine (1). The modifications performed on hippeastrine included some functional group transformations, structural simplification and preparation of dimers. All alkaloids were tested as potential antimalarial agents, being the hippeastrine dimers the most active compounds.",

keywords = "Amaryllidaceae alkaloids, Antiplasmodial activity, Hippeastrine, Lycorenine",

author = "Cedr{\'o}n, {Juan C.} and David Guti{\'e}rrez and {Flores Quisbert}, {Esther Ninoska Flores Quisbert} and Ravelo, {{\'A}ngel G.} and Ana Est{\'e}vez-Braun",

note = "Funding Information: This work has been partly funded by the Spanish MEC ( SAF 2009-13296-C02-01 ) and by the ICIC (Instituto Canario de Investigaci{\'o}n del C{\'a}ncer). ",

year = "2013",

doi = "10.1016/j.ejmech.2013.03.018",

language = "Ingl{\'e}s",

volume = "63",

pages = "722--730",

journal = "CHIM.THER.",

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publisher = "Elsevier Masson SAS",

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TY - JOUR

T1 - Preparation and antimalarial activity of semisynthetic lycorenine derivatives

AU - Cedrón, Juan C.

AU - Gutiérrez, David

AU - Flores Quisbert, Esther Ninoska Flores Quisbert

AU - Ravelo, Ángel G.

AU - Estévez-Braun, Ana

N1 - Funding Information: This work has been partly funded by the Spanish MEC ( SAF 2009-13296-C02-01 ) and by the ICIC (Instituto Canario de Investigación del Cáncer).

PY - 2013

Y1 - 2013

N2 - A set of twenty one lycorenine derivatives has been prepared from the alkaloid hippeastrine (1). The modifications performed on hippeastrine included some functional group transformations, structural simplification and preparation of dimers. All alkaloids were tested as potential antimalarial agents, being the hippeastrine dimers the most active compounds.

AB - A set of twenty one lycorenine derivatives has been prepared from the alkaloid hippeastrine (1). The modifications performed on hippeastrine included some functional group transformations, structural simplification and preparation of dimers. All alkaloids were tested as potential antimalarial agents, being the hippeastrine dimers the most active compounds.

KW - Amaryllidaceae alkaloids

KW - Antiplasmodial activity

KW - Hippeastrine

KW - Lycorenine

UR - http://www.scopus.com/inward/record.url?scp=84875932940&partnerID=8YFLogxK

U2 - 10.1016/j.ejmech.2013.03.018

DO - 10.1016/j.ejmech.2013.03.018

M3 - Artículo

C2 - 23567962

AN - SCOPUS:84875932940

VL - 63

SP - 722

EP - 730

JO - CHIM.THER.

JF - CHIM.THER.

SN - 0223-5234

ER -

Preparation and antimalarial activity of semisynthetic lycorenine derivatives

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