Platelet mediated killing of larvae from different filarial species in the presence of Dipetalonema viteae stimulated IgE antibodies

A. HAQUE, W. CUNA, B. BONNEL, A. CAPRON, M. JOSEPH

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

33 Citas (Scopus)

Resumen

Summary The platelets from normal rats interact with microfilariae of Dipetalonema viteae in vitro in the presence of antibodies leading to the killing of the parasite. The antibody involved in this reaction is identified as IgE because the absorption of immune rat serum on anti‐rat IgE column or the pretreatment of platelets with anti‐Fcɛ receptor resulted in a significant reduction in the percentage of killing of microfilariae. This antibody, which mediates platelet activity towards microfilariae, appears early in the secondary infection and persists for a short period of time. This short‐lasting IgE antibody is not apparently present in the form of large complexes since the supernatant but not the pellet after ultracentrifugation was able to mediate killing of microfilariae by platelets. IgE‐dependent platelet‐mediated parasite killing is neither stage‐ nor species‐specific because the microfilariae (LI) of Brugia malayi or of Loa loa and infective larvae (L3) of D. viteae or of B. malayi were killed when they were incubated with the serum obtained from rats at day 8 after secondary infection with adult D. viteae worms. The results of the present study suggest that platelets can actively participate in the immunological killing of filarial larvae.

Idioma originalInglés
Páginas (desde-hasta)517-526
Número de páginas10
PublicaciónParasite Immunology
Volumen7
N.º5
DOI
EstadoPublicada - sep. 1985
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Platelet mediated killing of larvae from different filarial species in the presence of Dipetalonema viteae stimulated IgE antibodies'. En conjunto forman una huella única.

Citar esto