Mulinane-type diterpenoids from Azorella compacta display antiplasmodial activity

Luis A. Loyola; Jorge Bórquez; Glauco Morales; Aurelio San-Martín; Jose Darias; Esther Ninoska Flores Quisbert Flores Quisbert; Alberto José Gimenez Turba

doi:10.1016/j.phytochem.2004.06.011

Mulinane-type diterpenoids from Azorella compacta display antiplasmodial activity

Luis A. Loyola, Jorge Bórquez, Glauco Morales, Aurelio San-Martín, Jose Darias, Esther Ninoska Flores Quisbert Flores Quisbert, Alberto José Gimenez Turba

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

45 Citas (Scopus)

Resumen

Two mulinane-type diterpenoids were isolated from Azorella compacta; namely 20-hydroxymulin-11,13-dienyl acetate and 13,14-dihydroxymulin-11-en-20-oic acid. The structures were elucidated by analysis of their spectroscopic data. These compounds, as well as three previously isolated diterpenes, were evaluated as potential in vivo growth inhibitors of Plasmodium berghei NK 65 on infected mice at an intraperitoneal dose of 10 mg/kg/day. Sixty percent and forty-two percent growth inhibition were obtained with 17-acetoxymulin-11,13-dien-20-oic acid and 13, 14-dihydroxymulin-11-en-20-oic acid, respectively.

Idioma original	Inglés
Páginas (desde-hasta)	1931-1935
Número de páginas	5
Publicación	Phytochemistry
Volumen	65
N.º	13
DOI	https://doi.org/10.1016/j.phytochem.2004.06.011
Estado	Publicada - jul. 2004

Nota bibliográfica

Funding Information:
This work was subsidized by the FONDECYT (Chile, Grant No. 1011068), Universidad de Antofagasta, CONICYT/CSIC (Grant 2002-3-073) and SECAB-CYTED (Grant C y T No. 1700 [K1-2002]). The work was developed as part of the Project X.5 from Subprogram X of CYTED. The field trip to Bolivia was supported by Agency Asdi/SAREC, Sweden.

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10.1016/j.phytochem.2004.06.011

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@article{6b82b33ea46a4d2d8620535fa01d445c,

title = "Mulinane-type diterpenoids from Azorella compacta display antiplasmodial activity",

abstract = "Two mulinane-type diterpenoids were isolated from Azorella compacta; namely 20-hydroxymulin-11,13-dienyl acetate and 13,14-dihydroxymulin-11-en-20-oic acid. The structures were elucidated by analysis of their spectroscopic data. These compounds, as well as three previously isolated diterpenes, were evaluated as potential in vivo growth inhibitors of Plasmodium berghei NK 65 on infected mice at an intraperitoneal dose of 10 mg/kg/day. Sixty percent and forty-two percent growth inhibition were obtained with 17-acetoxymulin-11,13-dien-20-oic acid and 13, 14-dihydroxymulin-11-en-20-oic acid, respectively.",

keywords = "Azorella compacta, Diterpenoids, Plasmodium berghei, Umbelliferae",

author = "Loyola, {Luis A.} and Jorge B{\'o}rquez and Glauco Morales and Aurelio San-Mart{\'i}n and Jose Darias and {Flores Quisbert}, {Esther Ninoska Flores Quisbert} and {Gimenez Turba}, {Alberto Jos{\'e}}",

note = "Funding Information: This work was subsidized by the FONDECYT (Chile, Grant No. 1011068), Universidad de Antofagasta, CONICYT/CSIC (Grant 2002-3-073) and SECAB-CYTED (Grant C y T No. 1700 [K1-2002]). The work was developed as part of the Project X.5 from Subprogram X of CYTED. The field trip to Bolivia was supported by Agency Asdi/SAREC, Sweden.",

year = "2004",

month = jul,

doi = "10.1016/j.phytochem.2004.06.011",

language = "Ingl{\'e}s",

volume = "65",

pages = "1931--1935",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd.",

number = "13",

}

TY - JOUR

T1 - Mulinane-type diterpenoids from Azorella compacta display antiplasmodial activity

AU - Loyola, Luis A.

AU - Bórquez, Jorge

AU - Morales, Glauco

AU - San-Martín, Aurelio

AU - Darias, Jose

AU - Flores Quisbert, Esther Ninoska Flores Quisbert

AU - Gimenez Turba, Alberto José

N1 - Funding Information: This work was subsidized by the FONDECYT (Chile, Grant No. 1011068), Universidad de Antofagasta, CONICYT/CSIC (Grant 2002-3-073) and SECAB-CYTED (Grant C y T No. 1700 [K1-2002]). The work was developed as part of the Project X.5 from Subprogram X of CYTED. The field trip to Bolivia was supported by Agency Asdi/SAREC, Sweden.

PY - 2004/7

Y1 - 2004/7

N2 - Two mulinane-type diterpenoids were isolated from Azorella compacta; namely 20-hydroxymulin-11,13-dienyl acetate and 13,14-dihydroxymulin-11-en-20-oic acid. The structures were elucidated by analysis of their spectroscopic data. These compounds, as well as three previously isolated diterpenes, were evaluated as potential in vivo growth inhibitors of Plasmodium berghei NK 65 on infected mice at an intraperitoneal dose of 10 mg/kg/day. Sixty percent and forty-two percent growth inhibition were obtained with 17-acetoxymulin-11,13-dien-20-oic acid and 13, 14-dihydroxymulin-11-en-20-oic acid, respectively.

AB - Two mulinane-type diterpenoids were isolated from Azorella compacta; namely 20-hydroxymulin-11,13-dienyl acetate and 13,14-dihydroxymulin-11-en-20-oic acid. The structures were elucidated by analysis of their spectroscopic data. These compounds, as well as three previously isolated diterpenes, were evaluated as potential in vivo growth inhibitors of Plasmodium berghei NK 65 on infected mice at an intraperitoneal dose of 10 mg/kg/day. Sixty percent and forty-two percent growth inhibition were obtained with 17-acetoxymulin-11,13-dien-20-oic acid and 13, 14-dihydroxymulin-11-en-20-oic acid, respectively.

KW - Azorella compacta

KW - Diterpenoids

KW - Plasmodium berghei

KW - Umbelliferae

UR - http://www.scopus.com/inward/record.url?scp=3242807303&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2004.06.011

DO - 10.1016/j.phytochem.2004.06.011

M3 - Artículo

C2 - 15280000

AN - SCOPUS:3242807303

VL - 65

SP - 1931

EP - 1935

JO - Phytochemistry

JF - Phytochemistry

SN - 0031-9422

IS - 13

ER -

Mulinane-type diterpenoids from Azorella compacta display antiplasmodial activity

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