Mulinane-type diterpenoids from Azorella compacta display antiplasmodial activity

Luis A. Loyola, Jorge Bórquez, Glauco Morales, Aurelio San-Martín, Jose Darias, Esther Ninoska Flores Quisbert Flores Quisbert, Alberto José Gimenez Turba

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

45 Citas (Scopus)

Resumen

Two mulinane-type diterpenoids were isolated from Azorella compacta; namely 20-hydroxymulin-11,13-dienyl acetate and 13,14-dihydroxymulin-11-en-20-oic acid. The structures were elucidated by analysis of their spectroscopic data. These compounds, as well as three previously isolated diterpenes, were evaluated as potential in vivo growth inhibitors of Plasmodium berghei NK 65 on infected mice at an intraperitoneal dose of 10 mg/kg/day. Sixty percent and forty-two percent growth inhibition were obtained with 17-acetoxymulin-11,13-dien-20-oic acid and 13, 14-dihydroxymulin-11-en-20-oic acid, respectively.

Idioma originalInglés
Páginas (desde-hasta)1931-1935
Número de páginas5
PublicaciónPhytochemistry
Volumen65
N.º13
DOI
EstadoPublicada - jul. 2004

Nota bibliográfica

Funding Information:
This work was subsidized by the FONDECYT (Chile, Grant No. 1011068), Universidad de Antofagasta, CONICYT/CSIC (Grant 2002-3-073) and SECAB-CYTED (Grant C y T No. 1700 [K1-2002]). The work was developed as part of the Project X.5 from Subprogram X of CYTED. The field trip to Bolivia was supported by Agency Asdi/SAREC, Sweden.

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