Metabolites from roots of Colubrina greggii var. Yucatanensis and Evaluation of their Antiprotozoan, Cytotoxic and antiproliferative activities

Dafne B. Domínguez-Carmona, Fabiola Escalante-Erosa, Karlina García-Sosa, Grace Ruiz-Pinell, David Gutierrez-Yapu, Manuel J. Chan-Bacab, Rosa E. Moo-Puc, Nigel C. Veitch, Alberto Giménez-Turba, Luis M. Peña-Rodríguez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

9 Citas (Scopus)

Resumen

Purification of the root extract of Colubrina greggii var. yucatanensis resulted in the isolation and identification of 3-O-acetyl ceanothic acid as a new natural ceanothane triterpene, together with the known metabolites ceanothic acid, cenothenic acid, betulinic acid, discarine B and chrysophanein. The natural products and the semisynthetic esters acetyl dimethyl ceanothate, dimethyl ceanothate and chrysophanein peracetate showed moderate to low leishmanicidal and trypanocidal activities. None of the metabolites showed cytotoxic or antiproliferative effects. The results also suggested that betulinic acid contributes to the antiplasmodial activity originally detected in the crude root extract of C. greggii var. yucatanensis.

Idioma originalInglés
Páginas (desde-hasta)1279-1285
Número de páginas7
PublicaciónJournal of the Brazilian Chemical Society
Volumen22
N.º7
DOI
EstadoPublicada - 2011

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