Kuehneromycins A and B, Two New Biological Active Compounds from a Tasmanian Kuehneromyces sp. (Strophariaceae, Basidiomycetes)

Gerhard Erkel, Kirsten Lorenzen, Timm Anke, Robert Velten, Alberto Gimenez, Wolfgang Steglich

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

21 Citas (Scopus)

Resumen

In a search for new inhibitors of RNA-directed DNA-polymerases kuehneromycin A (1) was isolated from fermentations of a Tasmanian Kuehneromyces species. Its structure was elucidated by spectroscopic methods. Kuehneromycin A (1) is a non-competitive inhibitor of avian myeloblastosis virus (Ki 200 μm) and moloney murine leukemia virus (Ki 40 μ) reverse transcriptases. The second compound, kuehneromycin B (2) is a strong inhibitor of platelet aggregation stimulated with different inducers. In addition, both compounds exhibit cytotoxic and antimicrobial activities.

Idioma originalInglés
Páginas (desde-hasta)1-10
Número de páginas10
PublicaciónZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volumen50
N.º1-2
DOI
EstadoPublicada - 1 feb. 1995
Publicado de forma externa

Nota bibliográfica

Funding Information:
The financial support of the Deutsche Forschungsgemeinschaft is gratefully acknowledged. A. G. thanks the Alexander von Humboldt-Foundation for a scholarship. We thank Drs Stegmeier and Dörge (Boehringer Mannheim) and their staff for providing facilities to perform the aggregation assays with human blood. We are grateful to Dr. B. Steffan and Mrs. R. Fröde for NMR and MS experiments.

Huella

Profundice en los temas de investigación de 'Kuehneromycins A and B, Two New Biological Active Compounds from a Tasmanian Kuehneromyces sp. (Strophariaceae, Basidiomycetes)'. En conjunto forman una huella única.

Citar esto