Kuehneromycins A and B, Two New Biological Active Compounds from a Tasmanian Kuehneromyces sp. (Strophariaceae, Basidiomycetes)

Gerhard Erkel; Kirsten Lorenzen; Timm Anke; Robert Velten; Alberto Gimenez; Wolfgang Steglich

doi:10.1515/znc-1995-1-202

Kuehneromycins A and B, Two New Biological Active Compounds from a Tasmanian Kuehneromyces sp. (Strophariaceae, Basidiomycetes)

Gerhard Erkel, Kirsten Lorenzen, Timm Anke, Robert Velten, Alberto Gimenez, Wolfgang Steglich

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

21 Citas (Scopus)

Resumen

In a search for new inhibitors of RNA-directed DNA-polymerases kuehneromycin A (1) was isolated from fermentations of a Tasmanian Kuehneromyces species. Its structure was elucidated by spectroscopic methods. Kuehneromycin A (1) is a non-competitive inhibitor of avian myeloblastosis virus (K_i 200 μm) and moloney murine leukemia virus (K_i 40 μ) reverse transcriptases. The second compound, kuehneromycin B (2) is a strong inhibitor of platelet aggregation stimulated with different inducers. In addition, both compounds exhibit cytotoxic and antimicrobial activities.

Idioma original	Inglés
Páginas (desde-hasta)	1-10
Número de páginas	10
Publicación	Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Volumen	50
N.º	1-2
DOI	https://doi.org/10.1515/znc-1995-1-202
Estado	Publicada - 1 feb. 1995
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
The financial support of the Deutsche Forschungsgemeinschaft is gratefully acknowledged. A. G. thanks the Alexander von Humboldt-Foundation for a scholarship. We thank Drs Stegmeier and Dörge (Boehringer Mannheim) and their staff for providing facilities to perform the aggregation assays with human blood. We are grateful to Dr. B. Steffan and Mrs. R. Fröde for NMR and MS experiments.

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title = "Kuehneromycins A and B, Two New Biological Active Compounds from a Tasmanian Kuehneromyces sp. (Strophariaceae, Basidiomycetes)",

abstract = "In a search for new inhibitors of RNA-directed DNA-polymerases kuehneromycin A (1) was isolated from fermentations of a Tasmanian Kuehneromyces species. Its structure was elucidated by spectroscopic methods. Kuehneromycin A (1) is a non-competitive inhibitor of avian myeloblastosis virus (Ki 200 μm) and moloney murine leukemia virus (Ki 40 μ) reverse transcriptases. The second compound, kuehneromycin B (2) is a strong inhibitor of platelet aggregation stimulated with different inducers. In addition, both compounds exhibit cytotoxic and antimicrobial activities.",

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author = "Gerhard Erkel and Kirsten Lorenzen and Timm Anke and Robert Velten and Alberto Gimenez and Wolfgang Steglich",

note = "Funding Information: The financial support of the Deutsche Forschungsgemeinschaft is gratefully acknowledged. A. G. thanks the Alexander von Humboldt-Foundation for a scholarship. We thank Drs Stegmeier and D{\"o}rge (Boehringer Mannheim) and their staff for providing facilities to perform the aggregation assays with human blood. We are grateful to Dr. B. Steffan and Mrs. R. Fr{\"o}de for NMR and MS experiments.",

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Kuehneromycins A and B, Two New Biological Active Compounds from a Tasmanian Kuehneromyces sp. (Strophariaceae, Basidiomycetes). / Erkel, Gerhard; Lorenzen, Kirsten; Anke, Timm et al.

En: Zeitschrift fur Naturforschung - Section C Journal of Biosciences, Vol. 50, N.º 1-2, 01.02.1995, p. 1-10.

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Kuehneromycins A and B, Two New Biological Active Compounds from a Tasmanian Kuehneromyces sp. (Strophariaceae, Basidiomycetes)

AU - Erkel, Gerhard

AU - Lorenzen, Kirsten

AU - Anke, Timm

AU - Velten, Robert

AU - Gimenez, Alberto

AU - Steglich, Wolfgang

N1 - Funding Information: The financial support of the Deutsche Forschungsgemeinschaft is gratefully acknowledged. A. G. thanks the Alexander von Humboldt-Foundation for a scholarship. We thank Drs Stegmeier and Dörge (Boehringer Mannheim) and their staff for providing facilities to perform the aggregation assays with human blood. We are grateful to Dr. B. Steffan and Mrs. R. Fröde for NMR and MS experiments.

PY - 1995/2/1

Y1 - 1995/2/1

N2 - In a search for new inhibitors of RNA-directed DNA-polymerases kuehneromycin A (1) was isolated from fermentations of a Tasmanian Kuehneromyces species. Its structure was elucidated by spectroscopic methods. Kuehneromycin A (1) is a non-competitive inhibitor of avian myeloblastosis virus (Ki 200 μm) and moloney murine leukemia virus (Ki 40 μ) reverse transcriptases. The second compound, kuehneromycin B (2) is a strong inhibitor of platelet aggregation stimulated with different inducers. In addition, both compounds exhibit cytotoxic and antimicrobial activities.

AB - In a search for new inhibitors of RNA-directed DNA-polymerases kuehneromycin A (1) was isolated from fermentations of a Tasmanian Kuehneromyces species. Its structure was elucidated by spectroscopic methods. Kuehneromycin A (1) is a non-competitive inhibitor of avian myeloblastosis virus (Ki 200 μm) and moloney murine leukemia virus (Ki 40 μ) reverse transcriptases. The second compound, kuehneromycin B (2) is a strong inhibitor of platelet aggregation stimulated with different inducers. In addition, both compounds exhibit cytotoxic and antimicrobial activities.

KW - Basidiomycetes

KW - Drimanes

KW - Kuehneromyces sp

KW - Nordrimanes

KW - Sesquiterpenoids

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Kuehneromycins A and B, Two New Biological Active Compounds from a Tasmanian Kuehneromyces sp. (Strophariaceae, Basidiomycetes)

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