Isolation of bis-indole alkaloids with antileishmanial and antibacterial activities from Peschiera van heurkii (Syn. Tabernaemontana van heurkii)

Victoria Muñoz Ortiz, C. Moretti, M. Sauvain, C. Caron, A. Porzel, G. Massiot, B. Richard, L. Le Men-Olivier

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

62 Citas (Scopus)

Resumen

Extracts from leaves and stem bark of Peschiera van heurkii (Muell. Alg.) L. Allorge (syn. Tabernaemontana van heurkii Muell. Arg., Apocynaceae) have been assayed for antileishmanial and antibacterial activities. The activities were concentrated in the alkaloid fractions which yielded 20 indole and bisindole alkaloids. The strongest leishmanicidal and antibacterial activities were observed with the dimeric alkaloids conodurine (1), N-demethylconodurine (= gabunine) (2), and conoduramine (3). Weak toxicity towards macrophage host cells and strong activity against the intracellular amastigote form of Leishmania were observed for compounds 1 and 2. In vivo, 1 was less active than glucantime (= N-methylglucamine antimonate), the drug of reference, while 2 was devoid of activity at 100 mg/kg.

Idioma originalInglés
Páginas (desde-hasta)455-459
Número de páginas5
PublicaciónPlanta Medica
Volumen60
N.º5
DOI
EstadoPublicada - 1994
Publicado de forma externa

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