In vitro antiplasmodial activity of sesquiterpene lactones from Ambrosia tenuifolia

V. Martino, V. Sülsen, D. Gutierrez Yappu, L. Laurella, C. Anesini, A. Gimenez Turba, L. Muschietti

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

14 Citas (Scopus)

Resumen

The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated. Peruvin was the most active compound on F32 strain of P. falciparum with a 50 inhibitory concentration value (IC50) of 0.3g/mL (1.1M) whereas psilostachyin showed activity on both strains (IC50 = 0.6 (2.1M) and 1.8g/mL (6.4M)). Fifty percent cytotoxic concentration (CC50) values (48h) were 6.8g/mL (24.3M) and 10.0g/mL (37.9M) for psilostachyin and peruvin, respectively.

Idioma originalInglés
Número de artículo352938
PublicaciónEvidence-based Complementary and Alternative Medicine
Volumen2011
DOI
EstadoPublicada - 2011

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