Hyphodontal, a New Antifungal Inhibitor of Reverse Transcriptases from Hyphodontia, sp. (Corticiaceae, Basidiomycetes)

Gerhard Erkel; Timm Anke; Robert Velten; Alberto Gimenez; Wolfgang Steglich

doi:10.1515/znc-1994-9-1005

Hyphodontal, a New Antifungal Inhibitor of Reverse Transcriptases from Hyphodontia, sp. (Corticiaceae, Basidiomycetes)

Gerhard Erkel, Timm Anke, Robert Velten, Alberto Gimenez, Wolfgang Steglich

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

14 Citas (Scopus)

Resumen

In a search for inhibitors of RNA-directed DNA polymerases a new isolactarane sesquiterpenoid, hyphodontal (1), was isolated from fermentations of a Canadian Hyphodontia, species. Its structure was elucidated by spectroscopic, methods. Hyphodontal strongly inhibits the growth of several yeasts and is a non-competitive inhibitor of avian myeloblastosis virus (K1 346 [formula omitted]) and Moloney murine leukemia virus (Ki 112 µM) reverse, transcriptases. In addition, cytotoxic and antifungal activities were, observed.

Idioma original	Inglés
Páginas (desde-hasta)	561-570
Número de páginas	10
Publicación	Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Volumen	49
N.º	9-10
DOI	https://doi.org/10.1515/znc-1994-9-1005
Estado	Publicada - oct. 1994
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
The financial support of the Deutsche Forschungsgemeinschaft is gratefully acknowledged. A. G. thanks the Alexander von Humboldt Foundation for a fellowship. We thank Prof. Dr. H. Anke and Prof. Dr. O. Sterner for providing several sesquiterpenoid dialdehydes for comparison.

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10.1515/znc-1994-9-1005

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title = "Hyphodontal, a New Antifungal Inhibitor of Reverse Transcriptases from Hyphodontia, sp. (Corticiaceae, Basidiomycetes)",

abstract = "In a search for inhibitors of RNA-directed DNA polymerases a new isolactarane sesquiterpenoid, hyphodontal (1), was isolated from fermentations of a Canadian Hyphodontia, species. Its structure was elucidated by spectroscopic, methods. Hyphodontal strongly inhibits the growth of several yeasts and is a non-competitive inhibitor of avian myeloblastosis virus (K1 346 [formula omitted]) and Moloney murine leukemia virus (Ki 112 µM) reverse, transcriptases. In addition, cytotoxic and antifungal activities were, observed.",

keywords = "Basidiomycetes, Hyphodontia sp, Isolactaranes, Reverse Transcriptases, Sesquiterpenes",

author = "Gerhard Erkel and Timm Anke and Robert Velten and Alberto Gimenez and Wolfgang Steglich",

note = "Funding Information: The financial support of the Deutsche Forschungsgemeinschaft is gratefully acknowledged. A. G. thanks the Alexander von Humboldt Foundation for a fellowship. We thank Prof. Dr. H. Anke and Prof. Dr. O. Sterner for providing several sesquiterpenoid dialdehydes for comparison.",

year = "1994",

month = oct,

doi = "10.1515/znc-1994-9-1005",

language = "Ingl{\'e}s",

volume = "49",

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Hyphodontal, a New Antifungal Inhibitor of Reverse Transcriptases from Hyphodontia, sp. (Corticiaceae, Basidiomycetes). / Erkel, Gerhard; Anke, Timm; Velten, Robert et al.

En: Zeitschrift fur Naturforschung - Section C Journal of Biosciences, Vol. 49, N.º 9-10, 10.1994, p. 561-570.

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Hyphodontal, a New Antifungal Inhibitor of Reverse Transcriptases from Hyphodontia, sp. (Corticiaceae, Basidiomycetes)

AU - Erkel, Gerhard

AU - Anke, Timm

AU - Velten, Robert

AU - Gimenez, Alberto

AU - Steglich, Wolfgang

N1 - Funding Information: The financial support of the Deutsche Forschungsgemeinschaft is gratefully acknowledged. A. G. thanks the Alexander von Humboldt Foundation for a fellowship. We thank Prof. Dr. H. Anke and Prof. Dr. O. Sterner for providing several sesquiterpenoid dialdehydes for comparison.

PY - 1994/10

Y1 - 1994/10

N2 - In a search for inhibitors of RNA-directed DNA polymerases a new isolactarane sesquiterpenoid, hyphodontal (1), was isolated from fermentations of a Canadian Hyphodontia, species. Its structure was elucidated by spectroscopic, methods. Hyphodontal strongly inhibits the growth of several yeasts and is a non-competitive inhibitor of avian myeloblastosis virus (K1 346 [formula omitted]) and Moloney murine leukemia virus (Ki 112 µM) reverse, transcriptases. In addition, cytotoxic and antifungal activities were, observed.

AB - In a search for inhibitors of RNA-directed DNA polymerases a new isolactarane sesquiterpenoid, hyphodontal (1), was isolated from fermentations of a Canadian Hyphodontia, species. Its structure was elucidated by spectroscopic, methods. Hyphodontal strongly inhibits the growth of several yeasts and is a non-competitive inhibitor of avian myeloblastosis virus (K1 346 [formula omitted]) and Moloney murine leukemia virus (Ki 112 µM) reverse, transcriptases. In addition, cytotoxic and antifungal activities were, observed.

KW - Basidiomycetes

KW - Hyphodontia sp

KW - Isolactaranes

KW - Reverse Transcriptases

KW - Sesquiterpenes

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U2 - 10.1515/znc-1994-9-1005

DO - 10.1515/znc-1994-9-1005

M3 - Artículo

C2 - 7524515

AN - SCOPUS:0028500781

VL - 49

SP - 561

EP - 570

JO - Zeitschrift fur Naturforschung. Section C: Biosciences

JF - Zeitschrift fur Naturforschung. Section C: Biosciences

SN - 0939-5075

IS - 9-10

ER -

Hyphodontal, a New Antifungal Inhibitor of Reverse Transcriptases from Hyphodontia, sp. (Corticiaceae, Basidiomycetes)

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