Effect of some bisbenzylisoquinoline alkaloids on American Leishmania sp. in BALB/c mice

Alain Fournet, Alcira Angelo Barrios, Victoria Muñoz Ortiz, Reynald Hocquemiller, André Cavé

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

30 Citas (Scopus)

Resumen

Four bisbenzylisoquinoline alkaloids, antioquine, berbamine, gyrocarpine and isotetrandrine were tested in BALB/c mice infected with Leishmania amazonensis (IFLA/BR/67/PH8 or MHOM/GF/84/CAY‐H‐142) or L. venezuelensis (VE/74/PM‐H3). The treatments were initiated 1 day after the parasitic infection, with alkaloid at 100 mg/kg/day for 14 days and the reference compound, meglumine antimonate (GlucantimeR) at 200 mg/kg/day. Antioquine, berbamine and gyrocarpine were less potent than Glucantime against L. amazonensis (PH8). Only isotetrandrine exhibited activity approximately equal to or greater than Glucantime in BALB/c mice infected with L. amazonensis (PH8 or H‐142) and showed significant activity against L. venezuelensis. Experiments with a single local treatment on the footpad, 2 weeks after parasitic infection with L. amazonensis (PH8), showed that isotetrandrine at 200 mg/kg was less active than Glucantime at 400 mg/kg.

Idioma originalInglés
Páginas (desde-hasta)281-284
Número de páginas4
PublicaciónPhytotherapy Research
Volumen7
N.º4
DOI
EstadoPublicada - 1993
Publicado de forma externa

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