Chagas' disease in Bolivia: Clinical and epidemiological features and zymodeme variability of Trypanosoma cruzi strains isolated from patients

S. F. Breniere, R. Carrasco, Magda Susana Revollo Zepita Revollo Zepita, G. Aparicio, P. Desjeux, M. Tibayrenc

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

48 Citas (Scopus)

Resumen

We performed serological and pathological studies on 495 patients with Chagas' disease from different areas of Bolivia. Eighty-nine Trypanosoma cruzi strains, isolated by xenodiagnosis, were characterized by 12 isoenzyme loci and were related to the presence of cardiac changes and enteric disease with megacolon. There was a high heterogeneity of human zymodemes, presenting evidence of 2 predominant zymodemes genetically dissimilar from each other and ubiquitous in Bolivia. The frequencies of these predominant zymodemes among strains from patients were compared to strains from triatomine bugs previously studied. We observed mixtures of different zymodemes within the same patient, a phenomenon seen previously in Bolivian patients. There was no apparent difference of pathogenicity between the 2 more frequent zymodemes isolated from humans.

Idioma originalInglés
Páginas (desde-hasta)521-529
Número de páginas9
PublicaciónAmerican Journal of Tropical Medicine and Hygiene
Volumen41
N.º5
DOI
EstadoPublicada - 1989
Publicado de forma externa

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