Benzochromenes from the roots of Bourreria pulchra

Gilda J. Erosa-Rejón, Alejandro Yam-Puc, Manuel J. Chan-Bacab, Alberto Giménez-Turbax, Efraín Salamanca, Luis M. Peña-Rodríguez, Olov Sterner

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

17 Citas (Scopus)


Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 μg/mL and 7.5 μg/mL, respectively).

Idioma originalInglés
Páginas (desde-hasta)9-12
Número de páginas4
PublicaciónPhytochemistry Letters
EstadoPublicada - 12 mar. 2010

Nota bibliográfica

Funding Information:
The authors wish to thank Paulino Simá-Polanco and Lourdes Morales-Dzul for collecting, identifying and preparing the plant material, as well as Fabiola Escalante-Erosa and Karlina García-Sosa, for technical assistance. G.E.-R. wishes to thank the European Commission for financial support via the EULADIV Alfa Project. The authors also gratefully acknowledge financial support from the Swedish Natural Science Research Council, the KAW foundation, the Swedish Foundation for International Cooperation in Research and Higher Education, and FOMIX-Yucatán Project No. 66262.


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