Arsenic exposure and metabolism among women in Bolivia

J. Gardon; N. Tirado; K. Broberg; M. Vahter

doi:10.1201/b20466-184

Arsenic exposure and metabolism among women in Bolivia

J. Gardon, N. Tirado, K. Broberg, M. Vahter

Resultado de la investigación: Capítulo del libro/informe/acta de congreso › Contribución a la conferencia › revisión exhaustiva

1 Cita (Scopus)

Resumen

Inorganic arsenic (iAs) in drinking water is found in south regions of Bolivia, but human exposure and metabolism efficiency remain unknown. Inefficient methylation of arsenic with a low fraction of DMA in urine is a susceptibility factor for toxic effects. To elucidate arsenic exposure and metabolism in different Bolivian population groups, 74 women from communities (Llapallapani, Pampa-Aullagas, Quillacas) around Lake Poopó were recruited. Arsenic exposure was assessed by the sum of arsenic metabolites (iAs, MMA, DMA) in urine (U-As) using HPLC-HG-ICPMS. The efficiency of arsenic metabolism was expressed as the percentages of the metabolites. The median U-As was 62.2, 62.3 and 83.9 μg/L and the median%DMA was 83.0, 81.3 and 79.1% in Llapallapani, Pampa Aullagas and Quillacas, respectively. Women in Llapallapani had a significantly higher fraction of DMA. The women showed elevated arsenic exposure and an efficient arsenic metabolism, which might influence their risk for arsenic-related disease.

Idioma original	Inglés
Título de la publicación alojada	Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
Editores	Prosun Bhattacharya, Gunnar Jacks, Jochen Bundschuh, Prosun Bhattacharya, Marie Vahter, Jerker Jarsjo, Jerker Jarsjo, Jurate Kumpiene, Arslan Ahmad, Charlotte Sparrenbom, Marinus Eric Donselaar, Jochen Bundschuh, Ravi Naidu, Ravi Naidu
Editorial	CRC Press/Balkema
Páginas	392-393
Número de páginas	2
ISBN (versión impresa)	9781138029415
DOI	https://doi.org/10.1201/b20466-184
Estado	Publicada - 2016
Evento	6th International Congress on Arsenic in the Environment, AS 2016 - Stockholm, Suecia Duración: 19 jun. 2016 → 23 jun. 2016

Serie de la publicación

Nombre	Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

Conferencia

Conferencia	6th International Congress on Arsenic in the Environment, AS 2016
País/Territorio	Suecia
Ciudad	Stockholm
Período	19/06/16 → 23/06/16

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Publisher Copyright:
© 2016 Taylor & Francis Group, London.

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10.1201/b20466-184

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Gardon, J., Tirado, N., Broberg, K., & Vahter, M. (2016). Arsenic exposure and metabolism among women in Bolivia. En P. Bhattacharya, G. Jacks, J. Bundschuh, P. Bhattacharya, M. Vahter, J. Jarsjo, J. Jarsjo, J. Kumpiene, A. Ahmad, C. Sparrenbom, M. E. Donselaar, J. Bundschuh, R. Naidu, & R. Naidu (Eds.), Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016 (pp. 392-393). (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016). CRC Press/Balkema. https://doi.org/10.1201/b20466-184

Gardon, J. ; Tirado, N. ; Broberg, K. et al. / Arsenic exposure and metabolism among women in Bolivia. Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. editor / Prosun Bhattacharya ; Gunnar Jacks ; Jochen Bundschuh ; Prosun Bhattacharya ; Marie Vahter ; Jerker Jarsjo ; Jerker Jarsjo ; Jurate Kumpiene ; Arslan Ahmad ; Charlotte Sparrenbom ; Marinus Eric Donselaar ; Jochen Bundschuh ; Ravi Naidu ; Ravi Naidu. CRC Press/Balkema, 2016. pp. 392-393 (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016).

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title = "Arsenic exposure and metabolism among women in Bolivia",

abstract = "Inorganic arsenic (iAs) in drinking water is found in south regions of Bolivia, but human exposure and metabolism efficiency remain unknown. Inefficient methylation of arsenic with a low fraction of DMA in urine is a susceptibility factor for toxic effects. To elucidate arsenic exposure and metabolism in different Bolivian population groups, 74 women from communities (Llapallapani, Pampa-Aullagas, Quillacas) around Lake Poop{\'o} were recruited. Arsenic exposure was assessed by the sum of arsenic metabolites (iAs, MMA, DMA) in urine (U-As) using HPLC-HG-ICPMS. The efficiency of arsenic metabolism was expressed as the percentages of the metabolites. The median U-As was 62.2, 62.3 and 83.9 μg/L and the median%DMA was 83.0, 81.3 and 79.1% in Llapallapani, Pampa Aullagas and Quillacas, respectively. Women in Llapallapani had a significantly higher fraction of DMA. The women showed elevated arsenic exposure and an efficient arsenic metabolism, which might influence their risk for arsenic-related disease.",

author = "J. Gardon and N. Tirado and K. Broberg and M. Vahter",

note = "Publisher Copyright: {\textcopyright} 2016 Taylor & Francis Group, London.; 6th International Congress on Arsenic in the Environment, AS 2016 ; Conference date: 19-06-2016 Through 23-06-2016",

year = "2016",

doi = "10.1201/b20466-184",

language = "Ingl{\'e}s",

isbn = "9781138029415",

series = "Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016",

publisher = "CRC Press/Balkema",

pages = "392--393",

editor = "Prosun Bhattacharya and Gunnar Jacks and Jochen Bundschuh and Prosun Bhattacharya and Marie Vahter and Jerker Jarsjo and Jerker Jarsjo and Jurate Kumpiene and Arslan Ahmad and Charlotte Sparrenbom and Donselaar, {Marinus Eric} and Jochen Bundschuh and Ravi Naidu and Ravi Naidu",

booktitle = "Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016",

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Gardon, J, Tirado, N, Broberg, K & Vahter, M 2016, Arsenic exposure and metabolism among women in Bolivia. En P Bhattacharya, G Jacks, J Bundschuh, P Bhattacharya, M Vahter, J Jarsjo, J Jarsjo, J Kumpiene, A Ahmad, C Sparrenbom, ME Donselaar, J Bundschuh, R Naidu & R Naidu (eds.), Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016, CRC Press/Balkema, pp. 392-393, 6th International Congress on Arsenic in the Environment, AS 2016, Stockholm, Suecia, 19/06/16. https://doi.org/10.1201/b20466-184

Arsenic exposure and metabolism among women in Bolivia. / Gardon, J.; Tirado, N.; Broberg, K. et al.
Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. ed. / Prosun Bhattacharya; Gunnar Jacks; Jochen Bundschuh; Prosun Bhattacharya; Marie Vahter; Jerker Jarsjo; Jerker Jarsjo; Jurate Kumpiene; Arslan Ahmad; Charlotte Sparrenbom; Marinus Eric Donselaar; Jochen Bundschuh; Ravi Naidu; Ravi Naidu. CRC Press/Balkema, 2016. p. 392-393 (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016).

Resultado de la investigación: Capítulo del libro/informe/acta de congreso › Contribución a la conferencia › revisión exhaustiva

TY - GEN

T1 - Arsenic exposure and metabolism among women in Bolivia

AU - Gardon, J.

AU - Tirado, N.

AU - Broberg, K.

AU - Vahter, M.

PY - 2016

Y1 - 2016

N2 - Inorganic arsenic (iAs) in drinking water is found in south regions of Bolivia, but human exposure and metabolism efficiency remain unknown. Inefficient methylation of arsenic with a low fraction of DMA in urine is a susceptibility factor for toxic effects. To elucidate arsenic exposure and metabolism in different Bolivian population groups, 74 women from communities (Llapallapani, Pampa-Aullagas, Quillacas) around Lake Poopó were recruited. Arsenic exposure was assessed by the sum of arsenic metabolites (iAs, MMA, DMA) in urine (U-As) using HPLC-HG-ICPMS. The efficiency of arsenic metabolism was expressed as the percentages of the metabolites. The median U-As was 62.2, 62.3 and 83.9 μg/L and the median%DMA was 83.0, 81.3 and 79.1% in Llapallapani, Pampa Aullagas and Quillacas, respectively. Women in Llapallapani had a significantly higher fraction of DMA. The women showed elevated arsenic exposure and an efficient arsenic metabolism, which might influence their risk for arsenic-related disease.

AB - Inorganic arsenic (iAs) in drinking water is found in south regions of Bolivia, but human exposure and metabolism efficiency remain unknown. Inefficient methylation of arsenic with a low fraction of DMA in urine is a susceptibility factor for toxic effects. To elucidate arsenic exposure and metabolism in different Bolivian population groups, 74 women from communities (Llapallapani, Pampa-Aullagas, Quillacas) around Lake Poopó were recruited. Arsenic exposure was assessed by the sum of arsenic metabolites (iAs, MMA, DMA) in urine (U-As) using HPLC-HG-ICPMS. The efficiency of arsenic metabolism was expressed as the percentages of the metabolites. The median U-As was 62.2, 62.3 and 83.9 μg/L and the median%DMA was 83.0, 81.3 and 79.1% in Llapallapani, Pampa Aullagas and Quillacas, respectively. Women in Llapallapani had a significantly higher fraction of DMA. The women showed elevated arsenic exposure and an efficient arsenic metabolism, which might influence their risk for arsenic-related disease.

UR - http://www.scopus.com/inward/record.url?scp=85016988313&partnerID=8YFLogxK

U2 - 10.1201/b20466-184

DO - 10.1201/b20466-184

M3 - Contribución a la conferencia

AN - SCOPUS:85016988313

SN - 9781138029415

T3 - Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

SP - 392

EP - 393

BT - Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

A2 - Bhattacharya, Prosun

A2 - Jacks, Gunnar

A2 - Bundschuh, Jochen

A2 - Bhattacharya, Prosun

A2 - Vahter, Marie

A2 - Jarsjo, Jerker

A2 - Kumpiene, Jurate

A2 - Ahmad, Arslan

A2 - Sparrenbom, Charlotte

A2 - Donselaar, Marinus Eric

A2 - Bundschuh, Jochen

A2 - Naidu, Ravi

PB - CRC Press/Balkema

T2 - 6th International Congress on Arsenic in the Environment, AS 2016

Y2 - 19 June 2016 through 23 June 2016

ER -

Gardon J, Tirado N, Broberg K, Vahter M. Arsenic exposure and metabolism among women in Bolivia. En Bhattacharya P, Jacks G, Bundschuh J, Bhattacharya P, Vahter M, Jarsjo J, Jarsjo J, Kumpiene J, Ahmad A, Sparrenbom C, Donselaar ME, Bundschuh J, Naidu R, Naidu R, editores, Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema. 2016. p. 392-393. (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016). doi: 10.1201/b20466-184

Arsenic exposure and metabolism among women in Bolivia

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