Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae

Edison Osorio, Gabriel Jaime Arango, Nora Jiménez, Fernando Alzate, Grace Ruiz, David Gutiérrez, Marco Antonio Paco, Alberto José Gimenez Turba, Sara Robledo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

111 Citas (Scopus)

Resumen

Ethnobotanical and chemotaxonomical studies for antiparasitic activity of Colombian Annonaceae were carried out. In vitro antiprotozoal activity of 36 extracts obtained from six different species was determined against promastigotes of three Leishmania species, epimastigotes of Trypanosoma cruzi and both chloroquine sensitive (F32) and resistant (W2) Plasmodium falciparum. Cytotoxic activity was evaluated in U-937 cells. Active extracts were selected according their selectivity index (SI). Extracts from Annona muricata, Rollinia exsucca, Rollinia pittieri and Xylopia aromatica were active against Leishmania spp. and Trypanosoma cruzi showing IC50 values lower than 25 μg/ml. Hexane extract from Rollinia pittieri leaves was the most selective against Trypanosoma cruzi and Leishmania spp. (IS = 10 and 16, respectively). The extracts from Desmopsis panamensis, Pseudomalmea boyacana, Rollinia exsucca and Rollinia pittieri showed good antiplasmodial activity (IC50 < 10 μg/ml). No correlation between antiplasmodial activity and inhibition of β-hematin production was found. The present study gives specific and useful information about antiprotozoal and cytotoxic activities of some Annonaceae extracts. Results presented here also demonstrate which plants and/or plant parts could be useful in the treatment of leishmaniasis, Chagas' disease and malaria.

Idioma originalInglés
Páginas (desde-hasta)630-635
Número de páginas6
PublicaciónJournal of Ethnopharmacology
Volumen111
N.º3
DOI
EstadoPublicada - 22 may. 2007

Nota bibliográfica

Funding Information:
This work was supported by COLCIENCIAS (Agreement No. RC 108-2003) and CODI-Universidad de Antioquia (Act No. CPT 0313).

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