TY - JOUR
T1 - Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae
AU - Osorio, Edison
AU - Arango, Gabriel Jaime
AU - Jiménez, Nora
AU - Alzate, Fernando
AU - Ruiz, Grace
AU - Gutiérrez, David
AU - Paco, Marco Antonio
AU - Gimenez Turba, Alberto José
AU - Robledo, Sara
N1 - Funding Information:
This work was supported by COLCIENCIAS (Agreement No. RC 108-2003) and CODI-Universidad de Antioquia (Act No. CPT 0313).
PY - 2007/5/22
Y1 - 2007/5/22
N2 - Ethnobotanical and chemotaxonomical studies for antiparasitic activity of Colombian Annonaceae were carried out. In vitro antiprotozoal activity of 36 extracts obtained from six different species was determined against promastigotes of three Leishmania species, epimastigotes of Trypanosoma cruzi and both chloroquine sensitive (F32) and resistant (W2) Plasmodium falciparum. Cytotoxic activity was evaluated in U-937 cells. Active extracts were selected according their selectivity index (SI). Extracts from Annona muricata, Rollinia exsucca, Rollinia pittieri and Xylopia aromatica were active against Leishmania spp. and Trypanosoma cruzi showing IC50 values lower than 25 μg/ml. Hexane extract from Rollinia pittieri leaves was the most selective against Trypanosoma cruzi and Leishmania spp. (IS = 10 and 16, respectively). The extracts from Desmopsis panamensis, Pseudomalmea boyacana, Rollinia exsucca and Rollinia pittieri showed good antiplasmodial activity (IC50 < 10 μg/ml). No correlation between antiplasmodial activity and inhibition of β-hematin production was found. The present study gives specific and useful information about antiprotozoal and cytotoxic activities of some Annonaceae extracts. Results presented here also demonstrate which plants and/or plant parts could be useful in the treatment of leishmaniasis, Chagas' disease and malaria.
AB - Ethnobotanical and chemotaxonomical studies for antiparasitic activity of Colombian Annonaceae were carried out. In vitro antiprotozoal activity of 36 extracts obtained from six different species was determined against promastigotes of three Leishmania species, epimastigotes of Trypanosoma cruzi and both chloroquine sensitive (F32) and resistant (W2) Plasmodium falciparum. Cytotoxic activity was evaluated in U-937 cells. Active extracts were selected according their selectivity index (SI). Extracts from Annona muricata, Rollinia exsucca, Rollinia pittieri and Xylopia aromatica were active against Leishmania spp. and Trypanosoma cruzi showing IC50 values lower than 25 μg/ml. Hexane extract from Rollinia pittieri leaves was the most selective against Trypanosoma cruzi and Leishmania spp. (IS = 10 and 16, respectively). The extracts from Desmopsis panamensis, Pseudomalmea boyacana, Rollinia exsucca and Rollinia pittieri showed good antiplasmodial activity (IC50 < 10 μg/ml). No correlation between antiplasmodial activity and inhibition of β-hematin production was found. The present study gives specific and useful information about antiprotozoal and cytotoxic activities of some Annonaceae extracts. Results presented here also demonstrate which plants and/or plant parts could be useful in the treatment of leishmaniasis, Chagas' disease and malaria.
KW - Annonaceae
KW - Antiplasmodial activity
KW - Colombian plants
KW - Leishmanicidal activity
KW - Trypanocidal activity
UR - http://www.scopus.com/inward/record.url?scp=34247179192&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2007.01.015
DO - 10.1016/j.jep.2007.01.015
M3 - Artículo
C2 - 17296281
AN - SCOPUS:34247179192
VL - 111
SP - 630
EP - 635
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
SN - 0378-8741
IS - 3
ER -