Antiplasmodial activity of naphthoquinones related to lapachol and β-lapachone

Elisa Pérez-Sacau, Ana Estévez-Braun, Ángel G. Ravelo, David Gutiérrez Yapu, Alberto Giménez Turba

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

129 Citas (Scopus)

Resumen

The in vitro antiplasmodial activity of 26 naphthoquinone derivatives related to the natural lapachol (1) and β-lapachone (2) was tested. Ten of these derivatives are reported for the first time. The evaluation was performed on cultures of F 32 strain of Plasmodium falciparum, and some derivatives displayed attractive in vitro activities (IC 50 < 10 μM). Based on these results, some structure - activity relationships have been determined.

Idioma originalInglés
Páginas (desde-hasta)264-274
Número de páginas11
PublicaciónChemistry and Biodiversity
Volumen2
N.º2
DOI
EstadoPublicada - 2005

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