Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant

Ivan Limachi; Claudia Condo; Camila Palma; Nelida Nina; Efrain Salamanca; Juan C. Ticona; Enrique Udaeta; Ninoska Flores; Alcides Serato; Natalio Marupa; Benigno Chao; Gladys Ibaguari; Constantino Nay; Soffie Manner; Olov Sterner; Alberto Giménez

doi:10.1177/1934578X1901400115

Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant

Ivan Limachi, Claudia Condo, Camila Palma, Nelida Nina, Efrain Salamanca, Juan C. Ticona, Enrique Udaeta, Ninoska Flores, Alcides Serato, Natalio Marupa, Benigno Chao, Gladys Ibaguari, Constantino Nay, Soffie Manner, Olov Sterner, Alberto Giménez

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Resumen

A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.

Idioma original	Inglés
Páginas (desde-hasta)	55-58
Número de páginas	4
Publicación	Natural Product Communications
Volumen	14
N.º	1
DOI	https://doi.org/10.1177/1934578X1901400115
Estado	Publicada - ene. 2019

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title = "Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant",

abstract = "A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.",

keywords = "Bolivia, Cytotoxicity, Giardia lamblia, Hyptis brevipes, Leishmania spp, Plasmodium falciparum, Tacana, Trypanosoma cruzi",

author = "Ivan Limachi and Claudia Condo and Camila Palma and Nelida Nina and Efrain Salamanca and Ticona, {Juan C.} and Enrique Udaeta and Ninoska Flores and Alcides Serato and Natalio Marupa and Benigno Chao and Gladys Ibaguari and Constantino Nay and Soffie Manner and Olov Sterner and Alberto Gim{\'e}nez",

year = "2019",

month = jan,

doi = "10.1177/1934578X1901400115",

language = "Ingl{\'e}s",

volume = "14",

pages = "55--58",

journal = "Natural Product Communications",

issn = "1934-578X",

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TY - JOUR

T1 - Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant

AU - Limachi, Ivan

AU - Condo, Claudia

AU - Palma, Camila

AU - Nina, Nelida

AU - Salamanca, Efrain

AU - Ticona, Juan C.

AU - Udaeta, Enrique

AU - Flores, Ninoska

AU - Serato, Alcides

AU - Marupa, Natalio

AU - Chao, Benigno

AU - Ibaguari, Gladys

AU - Nay, Constantino

AU - Manner, Soffie

AU - Sterner, Olov

AU - Giménez, Alberto

PY - 2019/1

Y1 - 2019/1

N2 - A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.

AB - A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.

KW - Bolivia

KW - Cytotoxicity

KW - Giardia lamblia

KW - Hyptis brevipes

KW - Leishmania spp

KW - Plasmodium falciparum

KW - Tacana

KW - Trypanosoma cruzi

UR - http://www.scopus.com/inward/record.url?scp=85063748149&partnerID=8YFLogxK

U2 - 10.1177/1934578X1901400115

DO - 10.1177/1934578X1901400115

M3 - Artículo

AN - SCOPUS:85063748149

SN - 1934-578X

VL - 14

SP - 55

EP - 58

JO - Natural Product Communications

JF - Natural Product Communications

IS - 1

ER -

Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant

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