Antileishmanial metabolites from Trixis antimenorrhoea

Eliana M. Maldonado, Efrain Salamanca, Alberto Giménez, Gloria Saavedra, Olov Sterner

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

7 Citas (Scopus)

Resumen

An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 μg/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol.

Idioma originalInglés
Páginas (desde-hasta)281-286
Número de páginas6
PublicaciónPhytochemistry Letters
Volumen10
DOI
EstadoPublicada - dic. 2014
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

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