TY - JOUR
T1 - Antileishmanial metabolites from Trixis antimenorrhoea
AU - Maldonado, Eliana M.
AU - Salamanca, Efrain
AU - Giménez, Alberto
AU - Saavedra, Gloria
AU - Sterner, Olov
N1 - Publisher Copyright:
© 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
PY - 2014/12
Y1 - 2014/12
N2 - An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 μg/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol.
AB - An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 μg/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol.
KW - Antileishmanial activity
KW - Nortrixane
KW - Structural elucidation
KW - Trixanolide
KW - Trixis antimenorrhoea
UR - http://www.scopus.com/inward/record.url?scp=84908454836&partnerID=8YFLogxK
U2 - 10.1016/j.phytol.2014.10.017
DO - 10.1016/j.phytol.2014.10.017
M3 - Artículo
AN - SCOPUS:84908454836
VL - 10
SP - 281
EP - 286
JO - Phytochemistry Letters
JF - Phytochemistry Letters
SN - 1874-3900
ER -