TY - JOUR
T1 - Antibiotics from basidiomycetes xl
T2 - Clavicoronic acid, a novel inhibitor of reverse transcriptases from clavicorona pyxidata (pers. ex fr.) doty
AU - Erkel, Gerhard
AU - Anke, Timm
AU - Gimenez Turba, Alberto José
AU - Steglich, Wolfgang
PY - 1992
Y1 - 1992
N2 - A novel inhibitor of RNA-directed DNA-polymerases was isolated from fermentations of Clavicorona pyxidata. Its structure was elucidated by spectroscopic methods. Clavicoronic acid (1) is a noncompetitive inhibitor of avian myeloblastosis virus (Ki 130 μM) and Moloney murine leukemia virus (Ki 68 μm) reverse transcriptases. In permeabilized cells and isolated nucleic DNA-and RNA-synthesis are not affected. Clavicoronic acid markedly inhibits the multiplication of vesicular stomatitis virus in baby hamster kidney cells by interfering with this virus's RNA-directed RNA-polymerase. 1 exhibits no cytotoxic and very weak antimicrobial activities.
AB - A novel inhibitor of RNA-directed DNA-polymerases was isolated from fermentations of Clavicorona pyxidata. Its structure was elucidated by spectroscopic methods. Clavicoronic acid (1) is a noncompetitive inhibitor of avian myeloblastosis virus (Ki 130 μM) and Moloney murine leukemia virus (Ki 68 μm) reverse transcriptases. In permeabilized cells and isolated nucleic DNA-and RNA-synthesis are not affected. Clavicoronic acid markedly inhibits the multiplication of vesicular stomatitis virus in baby hamster kidney cells by interfering with this virus's RNA-directed RNA-polymerase. 1 exhibits no cytotoxic and very weak antimicrobial activities.
UR - http://www.scopus.com/inward/record.url?scp=0026573183&partnerID=8YFLogxK
U2 - 10.7164/antibiotics.45.29
DO - 10.7164/antibiotics.45.29
M3 - Artículo
C2 - 1372310
AN - SCOPUS:0026573183
VL - 45
SP - 29
EP - 37
JO - Journal of Antibiotics
JF - Journal of Antibiotics
SN - 0021-8820
IS - 1
ER -