Antibiotics from basidiomycetes xl: Clavicoronic acid, a novel inhibitor of reverse transcriptases from clavicorona pyxidata (pers. ex fr.) doty

Gerhard Erkel, Timm Anke, Alberto José Gimenez Turba, Wolfgang Steglich

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

31 Citas (Scopus)

Resumen

A novel inhibitor of RNA-directed DNA-polymerases was isolated from fermentations of Clavicorona pyxidata. Its structure was elucidated by spectroscopic methods. Clavicoronic acid (1) is a noncompetitive inhibitor of avian myeloblastosis virus (Ki 130 μM) and Moloney murine leukemia virus (Ki 68 μm) reverse transcriptases. In permeabilized cells and isolated nucleic DNA-and RNA-synthesis are not affected. Clavicoronic acid markedly inhibits the multiplication of vesicular stomatitis virus in baby hamster kidney cells by interfering with this virus's RNA-directed RNA-polymerase. 1 exhibits no cytotoxic and very weak antimicrobial activities.

Idioma originalInglés
Páginas (desde-hasta)29-37
Número de páginas9
PublicaciónJournal of Antibiotics
Volumen45
N.º1
DOI
EstadoPublicada - 1992
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Antibiotics from basidiomycetes xl: Clavicoronic acid, a novel inhibitor of reverse transcriptases from clavicorona pyxidata (pers. ex fr.) doty'. En conjunto forman una huella única.

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