Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds

Esther del Olmo, Marlon García Armas, Jose Luis López-Pérez, Grace Ruiz, Fernando Vargas, Alberto José Gimenez Turba, Eric Deharo, Arturo San Feliciano

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

42 Citas (Scopus)

Resumen

We report the anti-Chagasic activity of the natural dihydrostilbenoid isonotholaenic acid and several simple derivatives, as well as that of some representative compounds of related synthetic series, with basic structures of benzalphthalides, dihydrostilbamides, isoindoles, phthalazin-1-ones, imidazo[2,1-a]isoindoles and pyrimido[2,1-a]isoindoles. The evaluation was performed in vitro on cultures of epimastigote and trypomastigote forms of Trypanosoma cruzi. Some of the tested compounds resulted to be as potent as benznidazole (epimastigotes), and others were shown to be more active than gentian violet (trypomastigotes), used as reference drugs.

Idioma originalInglés
Páginas (desde-hasta)2755-2757
Número de páginas3
PublicaciónBioorganic and Medicinal Chemistry Letters
Volumen11
N.º20
DOI
EstadoPublicada - 22 oct. 2001

Nota bibliográfica

Funding Information:
Financial support came from Spanish DGICYT (SAF 98/0103). M. G.-A. thanks the ICI-AECI (Spain) for a fellowship. Collaborative work was performed under the auspices of the Iberoamerican Program for Science and Technology (CYTED), SubProgram X. Biological evaluations were supported by the Institute de Recherche pour le Développement (IRD-France).

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