Actividad antiplasmódica in vitro e inhibición de la formación de la β-hematina de plantas Colombianas de la familia annonaceae

Edison Osorio, Gabriel Arango, Edison García, Katalina Muñoz, Grace Ruiz, David Gutiérrez, Marco Antonio Paco, Alberto José Gimenez Turba

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

3 Citas (Scopus)

Resumen

The antiplasmodial activity of 36 plant extracts related to the Annonaceae family was tested on chloroquine sensitive strain F32 and chloroquine resistant strain W2 of Plasmodium falciparum. The capacity of inhibition of β-hematin formation (Ifβ-h) was also evaluated comparing both activities by means of a statistical correlation study. Four extracts presented a potent activity against F32 and three only showed activity against W2, being the hexane stem bark extract of Rollinia exsucca the most active with CI50 values of 3.0 and 4.8 μg/ml against F32 and W2, respectively. Only the ethyl acetate leaves extract of Desmopsis panamensis showed Ifβ-h activity and growth inhibition of both strain, while the ethyl acetate stem bark extract of Rollinia pittieri presents Ifβ-h activity and growth inhibition of F32. A low correlation was observed among both activities.

Título traducido de la contribuciónIn vitro antiplasmodial activity and inhibition of β-hematin formation of Colombian plants of the family annonaceae
Idioma originalEspañol
Páginas (desde-hasta)527-532
Número de páginas6
PublicaciónActa Farmaceutica Bonaerense
Volumen24
N.º4
EstadoPublicada - oct. 2005

Palabras clave

  • β-hematin
  • Annonaceae
  • Antiplasmodial activity

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