A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part I. Evaluation of the antimalarial activity of plants used by the Chacobo Indians

Victoria Muñoz Ortiz, M. Sauvain, G. Bourdy, J. Callapa, S. Bergeron, I. Rojas, J. A. Bravo, L. Balderrama, B. Ortiz, Alberto José Gimenez Turba, E. Deharo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

108 Citas (Scopus)

Resumen

Thirty extracts of plants traditionally used by the Chacobos, a native community living in the Amazonian part of Bolivia, were screened in vitro and/or in vivo for antimalarial activity. Two of the four species designated as antimalarial, Geissospermum laeve and Maquira coriacea, displayed rather good activity, corroborating their traditional uses. However, they did show a rather high toxicity in vivo. Among twelve species used to cure symptoms relevant to malaria, five showed good activity: Apuleia leiocarpa, Bauhinia guianensis, Nectandra cuspidata, Sparattanthelium amazonum, Tanaecium jaroba. Two species, Qualea paraensis and Sclerolobium aff. guianense, used to treat scabies, showed interesting antimalarial activity in vivo; three other species (Iryanthera laevis, Prunus amplifolia, Pterocarpus aff. amazonum) used for various medicinal purposes, apparently not related with a Plasmodium infection, also showed antimalarial activity. Finally, one species (Derris amazonica) used as a piscicide displayed good in vitro activity, in the same way as one Annonaceae, Guatteria aff. schomburgkiana, used for construction purposes. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Idioma originalInglés
Páginas (desde-hasta)127-137
Número de páginas11
PublicaciónJournal of Ethnopharmacology
Volumen69
N.º2
DOI
EstadoPublicada - feb. 2000

Nota bibliográfica

Funding Information:
This project was financed by the International Foundation for Science, the Fondo Nacional del Medio Ambiente (FONAMA, Cuenta iniciativas para las Americas EIA), the Ministère Français des Affaires Etrangères, and IRD (Institut de Recherche pour le Développement).

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