A novel antiprotozoal aminosteroid from Saracha punctata

C. Moretti; M. Sauvain; C. Lavaud; G. Massiot; J. A. Bravo; Victoria Muñoz Ortiz

doi:10.1021/np9800654

A novel antiprotozoal aminosteroid from Saracha punctata

C. Moretti, M. Sauvain, C. Lavaud, G. Massiot, J. A. Bravo, Victoria Muñoz Ortiz

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

57 Citas (Scopus)

Resumen

A new aminosteroid, 3β-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-β-D-glucopyranosyl- eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 μM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 μM) and showed a strong in vitro antiplasmodial activity with an IC₅₀ of 25 nM.

Idioma original	Inglés
Páginas (desde-hasta)	1390-1393
Número de páginas	4
Publicación	Journal of Natural Products
Volumen	61
N.º	11
DOI	https://doi.org/10.1021/np9800654
Estado	Publicada - nov. 1998
Publicado de forma externa	Sí

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title = "A novel antiprotozoal aminosteroid from Saracha punctata",

abstract = "A new aminosteroid, 3β-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-β-D-glucopyranosyl- eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 μM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 μM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.",

author = "C. Moretti and M. Sauvain and C. Lavaud and G. Massiot and Bravo, {J. A.} and {Mu{\~n}oz Ortiz}, Victoria",

year = "1998",

month = nov,

doi = "10.1021/np9800654",

language = "Ingl{\'e}s",

volume = "61",

pages = "1390--1393",

journal = "Journal of Natural Products",

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T1 - A novel antiprotozoal aminosteroid from Saracha punctata

AU - Moretti, C.

AU - Sauvain, M.

AU - Lavaud, C.

AU - Massiot, G.

AU - Bravo, J. A.

AU - Muñoz Ortiz, Victoria

PY - 1998/11

Y1 - 1998/11

N2 - A new aminosteroid, 3β-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-β-D-glucopyranosyl- eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 μM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 μM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.

AB - A new aminosteroid, 3β-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-β-D-glucopyranosyl- eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 μM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 μM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.

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U2 - 10.1021/np9800654

DO - 10.1021/np9800654

M3 - Artículo

C2 - 9834160

AN - SCOPUS:0031791054

VL - 61

SP - 1390

EP - 1393

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 11

ER -

A novel antiprotozoal aminosteroid from Saracha punctata

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