A new focus of cutaneous leishmaniasis due to Leishmania amazonensis in a Sub Andean region of Bolivia

Eddy Octavio Martínez Avendaño Martínez Avendaño; F. Le Pont; M. Torrez; J. Tellería; F. Vargas; M. Muñoz; S. De Doncker; J. C. Dujardin; J. P. Dujardin

doi:10.1016/S0001-706X(98)00049-7

A new focus of cutaneous leishmaniasis due to Leishmania amazonensis in a Sub Andean region of Bolivia

Eddy Octavio Martínez Avendaño Martínez Avendaño, F. Le Pont, M. Torrez, J. Tellería, F. Vargas, M. Muñoz, S. De Doncker, J. C. Dujardin, J. P. Dujardin

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22 Citas (Scopus)

Resumen

We detected a new outbreak focus with high incidence of cutaneous leishmaniasis in the Sub Andean region of La Paz. This area was never considered previously as an endemic zone of leishmaniasis. Leishmania stocks from human lesions were isolated: three stocks were explored by pulse field gradient electrophoresis, showing evidence for their affiliation to the L. mexicana complex. Eight stocks were submitted to isoenzyme electrophoresis and compared with five reference strains: L. amazonensis, L. braziliensis, L. chagasi, L. mexicana and L. pifanoi. Close genetic proximity was evidenced between newly isolated parasites and the reference stock of L. amazonensis, whereas high divergence was observed between them and either the L. pifanoi, L. mexicana, L. braziliensis and L. chagasi reference strains. Copyright (C) 1998 Elsevier Science B.V.

Idioma original	Inglés
Páginas (desde-hasta)	97-106
Número de páginas	10
Publicación	Acta Tropica
Volumen	71
N.º	2
DOI	https://doi.org/10.1016/S0001-706X(98)00049-7
Estado	Publicada - 15 sep. 1998
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
We are grateful to Elfride Balanza (IBBA) who provided us with some additional reference strains, as well as to the ORSTOM unit at La Paz for field assistance. This investigation received financial support from the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, grant N° 940902. Karyotyping of parasites was performed with financial support from CEC, contract TS3-CT92-0219.

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title = "A new focus of cutaneous leishmaniasis due to Leishmania amazonensis in a Sub Andean region of Bolivia",

abstract = "We detected a new outbreak focus with high incidence of cutaneous leishmaniasis in the Sub Andean region of La Paz. This area was never considered previously as an endemic zone of leishmaniasis. Leishmania stocks from human lesions were isolated: three stocks were explored by pulse field gradient electrophoresis, showing evidence for their affiliation to the L. mexicana complex. Eight stocks were submitted to isoenzyme electrophoresis and compared with five reference strains: L. amazonensis, L. braziliensis, L. chagasi, L. mexicana and L. pifanoi. Close genetic proximity was evidenced between newly isolated parasites and the reference stock of L. amazonensis, whereas high divergence was observed between them and either the L. pifanoi, L. mexicana, L. braziliensis and L. chagasi reference strains. Copyright (C) 1998 Elsevier Science B.V.",

keywords = "Bolivia, Cutaneous leishmaniasis, L. amazonensis, Leishmania mexicana complex, Multilocus enzyme electrophoresis, Orthogonal field alternated gel electrophoresis",

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note = "Funding Information: We are grateful to Elfride Balanza (IBBA) who provided us with some additional reference strains, as well as to the ORSTOM unit at La Paz for field assistance. This investigation received financial support from the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, grant N° 940902. Karyotyping of parasites was performed with financial support from CEC, contract TS3-CT92-0219.",

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doi = "10.1016/S0001-706X(98)00049-7",

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T1 - A new focus of cutaneous leishmaniasis due to Leishmania amazonensis in a Sub Andean region of Bolivia

AU - Martínez Avendaño, Eddy Octavio Martínez Avendaño

AU - Le Pont, F.

AU - Torrez, M.

AU - Tellería, J.

AU - Vargas, F.

AU - Muñoz, M.

AU - De Doncker, S.

AU - Dujardin, J. C.

AU - Dujardin, J. P.

N1 - Funding Information: We are grateful to Elfride Balanza (IBBA) who provided us with some additional reference strains, as well as to the ORSTOM unit at La Paz for field assistance. This investigation received financial support from the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, grant N° 940902. Karyotyping of parasites was performed with financial support from CEC, contract TS3-CT92-0219.

PY - 1998/9/15

Y1 - 1998/9/15

N2 - We detected a new outbreak focus with high incidence of cutaneous leishmaniasis in the Sub Andean region of La Paz. This area was never considered previously as an endemic zone of leishmaniasis. Leishmania stocks from human lesions were isolated: three stocks were explored by pulse field gradient electrophoresis, showing evidence for their affiliation to the L. mexicana complex. Eight stocks were submitted to isoenzyme electrophoresis and compared with five reference strains: L. amazonensis, L. braziliensis, L. chagasi, L. mexicana and L. pifanoi. Close genetic proximity was evidenced between newly isolated parasites and the reference stock of L. amazonensis, whereas high divergence was observed between them and either the L. pifanoi, L. mexicana, L. braziliensis and L. chagasi reference strains. Copyright (C) 1998 Elsevier Science B.V.

AB - We detected a new outbreak focus with high incidence of cutaneous leishmaniasis in the Sub Andean region of La Paz. This area was never considered previously as an endemic zone of leishmaniasis. Leishmania stocks from human lesions were isolated: three stocks were explored by pulse field gradient electrophoresis, showing evidence for their affiliation to the L. mexicana complex. Eight stocks were submitted to isoenzyme electrophoresis and compared with five reference strains: L. amazonensis, L. braziliensis, L. chagasi, L. mexicana and L. pifanoi. Close genetic proximity was evidenced between newly isolated parasites and the reference stock of L. amazonensis, whereas high divergence was observed between them and either the L. pifanoi, L. mexicana, L. braziliensis and L. chagasi reference strains. Copyright (C) 1998 Elsevier Science B.V.

KW - Bolivia

KW - Cutaneous leishmaniasis

KW - L. amazonensis

KW - Leishmania mexicana complex

KW - Multilocus enzyme electrophoresis

KW - Orthogonal field alternated gel electrophoresis

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A new focus of cutaneous leishmaniasis due to Leishmania amazonensis in a Sub Andean region of Bolivia

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