Weekly iron supplementation is as effective as 5 day per week iron supplementation in Bolivian school children living at high altitude

J. Berger, V. M. Aguayo, W. Téllez, C. Luján, P. Traissac, J. L. San Miguel

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Objective: To compare the efficacy of a daily and a weekly iron supplementation on the hematological status of anemic children living at high altitude. Design: Double blind iron supplementation trial including a placebo control group. Setting: A socioeconomically disadvantaged district of La Pat, Bolivia (altitude of 4000 m). Subjects: Anemic (hemoglobin concentration ≤ 144 g/L), 3.3-8.3 y old children of both sexes. Intervention: Children received a placebo (n = 57) or a dose of 3-4 mg of elemental iron per kg body weight (FeSO4 tablets) 1 d per week (n = 58) or 5 d per week (n = 58) for 16 weeks. Results: Hemoglobin and zinc erythrocyte protoporphyrin concentrations improved significantly in supplemented groups but not in the placebo group. Changes in hemoglobin during the study were not significantly different between supplemented groups (weekly group: 15.2 ± 6.9 g/L and daily group: 18.6 ± 11.1 g/L) but were different from the placebo group (0.5 ± 7.1 g/L, P < 0.001). At the end of the supplementation period, the hemoglobin distribution was Gaussian, and similar in both supplemented groups. Adjusting for the initial hemoglobin concentration, final hemoglobin and its changes were similar in both supplemented groups. Conclusion: Weekly iron supplementation is as efficacious as daily iron supplementation in improving iron status and correcting moderate iron deficiency anemia in Bolivian school children living at high altitude.

Original languageEnglish
Pages (from-to)381-386
Number of pages6
JournalEuropean Journal of Clinical Nutrition
Volume51
Issue number6
DOIs
StatePublished - Jun 1997
Externally publishedYes

Bibliographical note

Funding Information:
Objective: To compare the efficacy of a daily and a weekly iron supplementation on the hematological status of anemic children living at high altitude. Design: Double blind iron supplementation trial including a placebo control group. Setting: A socioeconomically disadvantaged district of La Paz, Bolivia (altitude of 4000 m). Subjects: Anemic (hemoglobin concentration ≤ 144 g/L), 3.3–8.3 y old children of both sexes. Intervention: Children received a placebo (n ˆ 57) or a dose of 3–4 mg of elemental iron per kg body weight (FeSO4 tablets) 1 d per week (n ˆ 58) or 5 d per week (n ˆ 58) for 16 weeks. Results: Hemoglobin and zinc erythrocyte protoporphyrin concentrations improved significantly in supplemented groups but not in the placebo group. Changes in hemoglobin during the study were not significantly different between supplemented groups (weekly group: 15.2 ± 6.9 g/L and daily group: 18.6 ± 11.1 g/L) but were different from the placebo group (0.5 ± 7.1 g/L, P < 0.001). At the end of the supplementation period, the hemoglobin distribution was Gaussian, and similar in both supplemented groups. Adjusting for the initial hemoglobin concentration, final hemoglobin and its changes were similar in both supplemented groups. Conclusion: Weekly iron supplementation is as efficacious as daily iron supplementation in improving iron status and correcting moderate iron deficiency anemia in Bolivian school children living at high altitude. Sponsorship: Program supported in part by ORSTROM, the French Ministry of Foreign Affairs and the National Secretary's Office of Health, Bolivia. Descriptors: anemia; iron; weekly supplementation; school children; altitude

Keywords

  • Altitude
  • Anemia
  • Iron
  • School children
  • Weekly supplementation

Fingerprint

Dive into the research topics of 'Weekly iron supplementation is as effective as 5 day per week iron supplementation in Bolivian school children living at high altitude'. Together they form a unique fingerprint.

Cite this