Trypanocidal activity of South American Vernonieae (Asteraceae) extracts and its sesquiterpene lactones

Andrea Sosa, Efraín Salamanca Capusiri, Susana Amaya, Alicia Bardón, Alberto Giménez-Turba, Nancy Vera, Susana Borkosky

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4 Scopus citations

Abstract

Chagas disease is caused by Trypanosoma cruzi and affects the poorest population in the Americas. Fourteen plant extracts and seventeen sesquiterpene lactones from the tribe Vernonieae (Asteraceae), were evaluated for the first time against T. cruzi. Cytotoxicity employing HeLa cells was also assessed. The best results were obtained with leaves and flowers rinse extracts from Vernonanthura nebularum (E-1 and E-3) and Elephantopus mollis (E-11 and E-13), with IC50 values <2 µg/mL, being E-1 the most active (IC50 = 0.8 µg/mL). Additionally, these extracts displayed a good selectivity (SI > 10). The most active sesquiterpene lactones, isolated from the extracts, were 2 (2-methoxy-2,5-epoxy-8-methacryloxygermacra-3Z,11(13)-dien-6,12-olide) and 6 (2-ethoxy-2,5-epoxy-8-angeloxygermacra-3Z,11(13)-dien-6,12-olide) from V. nebularum and 12 (8α-methacryloxyhirsutinolide 13-O-acetate) from V. pinguis, with IC50 of 1.5, 2.1 and 2.0 µM, respectively. These compounds showed SI values >14, better than those of the reference drug nifurtimox. Plants living in South American ecosystems could become a potential source of trypanocidal agents.

Original languageEnglish
Pages (from-to)5224-5228
Number of pages5
JournalNatural Product Research
Volume35
Issue number23
DOIs
StatePublished - 2021

Bibliographical note

Funding Information:
This work was supported by CONICET [Grant PIP-533] and SCAIT, UNT [Grant PIUNT D 552-2]. The authors would like to thank Biochemists C. Palma and C. Condo Montero (IIFB-UMSA) for their help with biological assays and LISA (UNT-CONICET) for the spectroscopic determinations.

Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Asteraceae
  • Hela cells
  • Trypanosoma cruzi
  • Vernonieae
  • antiparasitic
  • sesquiterpene lactones

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