The imidazo[2,1-a]isoindole system. A new skeletal basis for antiplasmodial compounds

Esther Del Olmo; Marlon García Armas; Ma Inés Ybarra; Josè Luis López; Patricia Oporto; Alberto José Gimenez Turba; Eric Deharo; Arturo San Feliciano

doi:10.1016/S0960-894X(03)00509-2

The imidazo[2,1-a]isoindole system. A new skeletal basis for antiplasmodial compounds

Esther Del Olmo, Marlon García Armas, Ma Inés Ybarra, Josè Luis López, Patricia Oporto, Alberto José Gimenez Turba, Eric Deharo, Arturo San Feliciano

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The in vitro antiplasmodial activity of some dihydrostilbenamides, phtalazinones, imidazo[2,1-a]isoindole and pyrimido[2,1-a]isoindole derivatives related to the natural dihydrostilbenoid isonotholaenic acid is reported. The evaluation was performed on cultures of F32 strain of Plasmodium falciparum and potent representative compounds were also evaluated in the ferriprotoporphyrin IX biomineralization inhibition test (FBIT). Compounds having the imidazo[2,1-a]isoindole skeleton were the most active and one compound of this group resulted to be as potent as chloroquine, but acting through a mechanism different that of the inhibition of heme biomineralization.

Original language	English
Pages (from-to)	2769-2772
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	16
DOIs	https://doi.org/10.1016/S0960-894X(03)00509-2
State	Published - 18 Aug 2003

Bibliographical note

Funding Information:
M.G.A. thanks AECI (Spain) for a fellowship. M.I.Y. thanks the University of Tucuman (Argentina) for the support. Financial support of the chemical part came from Spanish DGICYT (SAF 98/0103). Biological evaluations were supported by the Institut de Recherche pour le Développement (IRD-France) and the OAS (OEA-Regional Flora). This collaborative work has been performed under the auspices of the Ibero-American Program of Science and Technology for Development (CYTED), Sub-Program X.

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title = "The imidazo[2,1-a]isoindole system. A new skeletal basis for antiplasmodial compounds",

abstract = "The in vitro antiplasmodial activity of some dihydrostilbenamides, phtalazinones, imidazo[2,1-a]isoindole and pyrimido[2,1-a]isoindole derivatives related to the natural dihydrostilbenoid isonotholaenic acid is reported. The evaluation was performed on cultures of F32 strain of Plasmodium falciparum and potent representative compounds were also evaluated in the ferriprotoporphyrin IX biomineralization inhibition test (FBIT). Compounds having the imidazo[2,1-a]isoindole skeleton were the most active and one compound of this group resulted to be as potent as chloroquine, but acting through a mechanism different that of the inhibition of heme biomineralization.",

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AU - Armas, Marlon García

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AU - López, Josè Luis

AU - Oporto, Patricia

AU - Gimenez Turba, Alberto José

AU - Deharo, Eric

AU - San Feliciano, Arturo

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ER -

The imidazo[2,1-a]isoindole system. A new skeletal basis for antiplasmodial compounds

Abstract

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