Synergistic effect of lupenone and caryophyllene oxide against Trypanosoma cruzi

Glendy Polanco-Hernández, Fabiola Escalante-Erosa, Karlina García-Sosa, María E. Rosado, Eugenia Guzmán-Marín, Karla Y. Acosta-Viana, Alberto Giménez-Turba, Efraín Salamanca, Luis M. Peña-Rodríguez

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16 Scopus citations

Abstract

The in vitro trypanocidal activity of a 1: 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50=10.4 g/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of amastigote nests in cardiac tissue and skeletal muscle of infected mice showed a reduction of more than 80% at a dose level of 20.8 mg·kg -1·day-1.

Original languageEnglish
Article number435398
JournalEvidence-based Complementary and Alternative Medicine
Volume2013
DOIs
StatePublished - 2013

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