TY - JOUR
T1 - Synergistic effect of lupenone and caryophyllene oxide against Trypanosoma cruzi
AU - Polanco-Hernández, Glendy
AU - Escalante-Erosa, Fabiola
AU - García-Sosa, Karlina
AU - Rosado, María E.
AU - Guzmán-Marín, Eugenia
AU - Acosta-Viana, Karla Y.
AU - Giménez-Turba, Alberto
AU - Salamanca, Efraín
AU - Peña-Rodríguez, Luis M.
PY - 2013
Y1 - 2013
N2 - The in vitro trypanocidal activity of a 1: 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50=10.4 g/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of amastigote nests in cardiac tissue and skeletal muscle of infected mice showed a reduction of more than 80% at a dose level of 20.8 mg·kg -1·day-1.
AB - The in vitro trypanocidal activity of a 1: 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50=10.4 g/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of amastigote nests in cardiac tissue and skeletal muscle of infected mice showed a reduction of more than 80% at a dose level of 20.8 mg·kg -1·day-1.
UR - http://www.scopus.com/inward/record.url?scp=84878691440&partnerID=8YFLogxK
U2 - 10.1155/2013/435398
DO - 10.1155/2013/435398
M3 - Artículo
AN - SCOPUS:84878691440
VL - 2013
JO - Evidence-based Complementary and Alternative Medicine
JF - Evidence-based Complementary and Alternative Medicine
SN - 1741-427X
M1 - 435398
ER -