Small pulmonary arteries in some natives of La Paz, Bolivia

D. Heath, P. Smith, J. Rios Dalenz, D. Williams, P. Harris

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


A histological study was made of the small pulmonary blood vessels in pieces of lung obtained at necropsy from 19 long-term residents of La Paz, Bolivia (3800 m). There was variation in the response of the pulmonary vasculature of these subjects to the chronic hypoxia of high altitude. The most characteristic finding, seen in seven of the 16 cases beyond infancy, was distal extension of vascular smooth muscle into pulmonary arterioles as small as 20 μm in diameter. Medial hypertrophy of the muscular pulmonary arteries occurred in only three of these seven subjects. Intimal fibrosis was seen in eight of the 19 cases and was ascribed to age; such fibrotic proliferation may affect the reversibility of hypoxic pulmonary hypertension and associated vascular changes in highlanders.

Original languageEnglish
Pages (from-to)599-604
Number of pages6
JournalUnknown Journal
Issue number8
StatePublished - 1981
Externally publishedYes


Dive into the research topics of 'Small pulmonary arteries in some natives of La Paz, Bolivia'. Together they form a unique fingerprint.

Cite this