Serodiagnosis of Chronic and Acute Chagas' Disease with Trypanosoma cruzi Recombinant Proteins: Results of a Collaborative Study in Six Latin American Countries

Eufrosina S. Umezawa, Alejandro O. Luquetti, Gabriela Levitus, Carlos Ponce, Elisa Ponce, Diana Henriquez, Susana Revollo, Bertha Espinoza, Octavio Sousa, Baldip Khan, José Franco Da Silveira

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

An enzyme-linked immunosorbent assay to diagnose Chagas' disease by a serological test was performed with Trypanosoma cruzi recombinant antigens (JL8, MAP, and TcPo). High sensitivity (99.4%) and specificity (99.3%) were obtained when JL8 was combined with MAP (JM) and tested with 150 serum samples from chagasic and 142 nonchagasic individuals. Moreover, JM also diagnosed 84.2% of patients in the acute phase of T. cruzi infection.

Original languageEnglish
Pages (from-to)449-452
Number of pages4
JournalJournal of Clinical Microbiology
Volume42
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

Fingerprint

Dive into the research topics of 'Serodiagnosis of Chronic and Acute Chagas' Disease with Trypanosoma cruzi Recombinant Proteins: Results of a Collaborative Study in Six Latin American Countries'. Together they form a unique fingerprint.

Cite this