Screening of South American plants against human immunodeficiency virus: Preliminary fractionation of aqueous extract from Baccharis trinervis

Sonsoles Sanchez Palomino; María José Abad; Luis Miguel Bedoya; Javier García; Eduardo Gonzales; Ximena Chiriboga; Paulina Bermejo; José Alcami

doi:10.1248/bpb.25.1147

Screening of South American plants against human immunodeficiency virus: Preliminary fractionation of aqueous extract from Baccharis trinervis

Sonsoles Sanchez Palomino, María José Abad, Luis Miguel Bedoya, Javier García, Eduardo Gonzales, Ximena Chiriboga, Paulina Bermejo, José Alcami

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Ethanolic and aqueous extracts of 14 South American medicinal plants were tested for inhibitory activity on human immunodeficiency virus (HIV). Both extracts were relatively non-toxic to human lymphocytic MT-2 cells, but only the aqueous extract of Baccharis trinervis exhibited potent anti-HIV activity in an in vitro MTT assay. To delineate the extract-sensitive phase, some studies of the antiviral properties of the active extract are described in this paper. Based on the results presented here, a separation scheme was devised, which permitted the preliminary fractionation of the extract, with the aim of finding an inhibitor of this virus.

Original language	English
Pages (from-to)	1147-1150
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	25
Issue number	9
DOIs	https://doi.org/10.1248/bpb.25.1147
State	Published - Sep 2002

Keywords

AIDS
Antiviral activity
Baccharis trinervis
HIV
South American medicinal plant

UN SDGs

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10.1248/bpb.25.1147

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title = "Screening of South American plants against human immunodeficiency virus: Preliminary fractionation of aqueous extract from Baccharis trinervis",

abstract = "Ethanolic and aqueous extracts of 14 South American medicinal plants were tested for inhibitory activity on human immunodeficiency virus (HIV). Both extracts were relatively non-toxic to human lymphocytic MT-2 cells, but only the aqueous extract of Baccharis trinervis exhibited potent anti-HIV activity in an in vitro MTT assay. To delineate the extract-sensitive phase, some studies of the antiviral properties of the active extract are described in this paper. Based on the results presented here, a separation scheme was devised, which permitted the preliminary fractionation of the extract, with the aim of finding an inhibitor of this virus.",

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Screening of South American plants against human immunodeficiency virus : Preliminary fractionation of aqueous extract from Baccharis trinervis. / Sanchez Palomino, Sonsoles; Abad, María José; Bedoya, Luis Miguel et al.

In: Biological and Pharmaceutical Bulletin, Vol. 25, No. 9, 09.2002, p. 1147-1150.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Screening of South American plants against human immunodeficiency virus

T2 - Preliminary fractionation of aqueous extract from Baccharis trinervis

AU - Sanchez Palomino, Sonsoles

AU - Abad, María José

AU - Bedoya, Luis Miguel

AU - García, Javier

AU - Gonzales, Eduardo

AU - Chiriboga, Ximena

AU - Bermejo, Paulina

AU - Alcami, José

PY - 2002/9

Y1 - 2002/9

N2 - Ethanolic and aqueous extracts of 14 South American medicinal plants were tested for inhibitory activity on human immunodeficiency virus (HIV). Both extracts were relatively non-toxic to human lymphocytic MT-2 cells, but only the aqueous extract of Baccharis trinervis exhibited potent anti-HIV activity in an in vitro MTT assay. To delineate the extract-sensitive phase, some studies of the antiviral properties of the active extract are described in this paper. Based on the results presented here, a separation scheme was devised, which permitted the preliminary fractionation of the extract, with the aim of finding an inhibitor of this virus.

AB - Ethanolic and aqueous extracts of 14 South American medicinal plants were tested for inhibitory activity on human immunodeficiency virus (HIV). Both extracts were relatively non-toxic to human lymphocytic MT-2 cells, but only the aqueous extract of Baccharis trinervis exhibited potent anti-HIV activity in an in vitro MTT assay. To delineate the extract-sensitive phase, some studies of the antiviral properties of the active extract are described in this paper. Based on the results presented here, a separation scheme was devised, which permitted the preliminary fractionation of the extract, with the aim of finding an inhibitor of this virus.

KW - AIDS

KW - Antiviral activity

KW - Baccharis trinervis

KW - HIV

KW - South American medicinal plant

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SN - 0918-6158

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Screening of South American plants against human immunodeficiency virus: Preliminary fractionation of aqueous extract from Baccharis trinervis

Abstract

Keywords

UN SDGs

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