TY - JOUR
T1 - Screening of Latin American plants for antiparasitic activities against malaria, Chagas disease, and leishmaniasis
AU - Calderón, Ángela I.
AU - Romero, Luz I.
AU - Ortega-Barría, Eduardo
AU - Solís, Pablo N.
AU - Zacchino, Susana
AU - Gimenez, Alberto
AU - Pinzón, Roberto
AU - Cáceres, Armando
AU - Tamayo, Giselle
AU - Guerra, Carlos
AU - Espinosa, Alex
AU - Correa, Mireya
AU - Gupta, Mahabir P.
N1 - Funding Information:
This work was supported by the Organization of American States (OAS) through the multinational project “Aprovechamiento de la Flora Regional como Fuente de Moléculas Antifúngicas, Antiparasitarias y Anticancer” (SEDI/AICD/106/01).
PY - 2010/5
Y1 - 2010/5
N2 - In order to explore rationally the medical potential of the plant biodiversity of the Central and South American region as a source of novel antiparasitic molecules, a multinational Organization of American States (OAS) project, which included the participation of multidisciplinary research centers from Argentina, Bolivia, Colombia, Costa Rica, Guatemala, Nicaragua and Panama, was carried out during the period 2001-2004. This project aimed at screening organic plant extracts for antitrypanosomal, antileishmanial and antimalarial activities and subsequently isolating and characterizing bioactive molecules. Plants for antiparasitic screening were selected from a database of ethnomedical uses of Latin American plants (PlanMedia) based on the amount of biological and chemical information available in the literature. We report here the evaluation of 452 extracts from 311 plant species in vitro screens against Plasmodium falciparum, Leishmania mexicana, and Trypanosoma cruzi. Out of 311 species tested, 17 plants (5.4%) showed antiparasitic activities at IC50 values≤10g/mL. The most active plants were Acnistus arborescens (L.) Schltdl. (Solanaceae) (leaf, EtOH, IC50: 4g/mL) Monochaetum myrtoideum Naudin (Melastomataceae) (leaf, MeOH, IC50: 5g/mL) and Bourreria huanita (Lex.) Hemsl. (Boraginaceae) (branch, EtOH, IC50: 6g/mL). These were selectively active against P. falciparum, L. mexicana and T. cruzi, respectively.
AB - In order to explore rationally the medical potential of the plant biodiversity of the Central and South American region as a source of novel antiparasitic molecules, a multinational Organization of American States (OAS) project, which included the participation of multidisciplinary research centers from Argentina, Bolivia, Colombia, Costa Rica, Guatemala, Nicaragua and Panama, was carried out during the period 2001-2004. This project aimed at screening organic plant extracts for antitrypanosomal, antileishmanial and antimalarial activities and subsequently isolating and characterizing bioactive molecules. Plants for antiparasitic screening were selected from a database of ethnomedical uses of Latin American plants (PlanMedia) based on the amount of biological and chemical information available in the literature. We report here the evaluation of 452 extracts from 311 plant species in vitro screens against Plasmodium falciparum, Leishmania mexicana, and Trypanosoma cruzi. Out of 311 species tested, 17 plants (5.4%) showed antiparasitic activities at IC50 values≤10g/mL. The most active plants were Acnistus arborescens (L.) Schltdl. (Solanaceae) (leaf, EtOH, IC50: 4g/mL) Monochaetum myrtoideum Naudin (Melastomataceae) (leaf, MeOH, IC50: 5g/mL) and Bourreria huanita (Lex.) Hemsl. (Boraginaceae) (branch, EtOH, IC50: 6g/mL). These were selectively active against P. falciparum, L. mexicana and T. cruzi, respectively.
KW - Antiparasitic activity
KW - Chagas disease
KW - Latin America
KW - Leishmaniasis
KW - Malaria
KW - Screening
UR - http://www.scopus.com/inward/record.url?scp=77951782337&partnerID=8YFLogxK
U2 - 10.3109/13880200903193344
DO - 10.3109/13880200903193344
M3 - Artículo
C2 - 20645798
AN - SCOPUS:77951782337
SN - 1388-0209
VL - 48
SP - 545
EP - 553
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
IS - 5
ER -