Preparation and antimalarial activity of semisynthetic lycorenine derivatives

Juan C. Cedrón, David Gutiérrez, Esther Ninoska Flores Quisbert Flores Quisbert, Ángel G. Ravelo, Ana Estévez-Braun

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


A set of twenty one lycorenine derivatives has been prepared from the alkaloid hippeastrine (1). The modifications performed on hippeastrine included some functional group transformations, structural simplification and preparation of dimers. All alkaloids were tested as potential antimalarial agents, being the hippeastrine dimers the most active compounds.

Original languageEnglish
Pages (from-to)722-730
Number of pages9
JournalEuropean Journal of Medicinal Chemistry
StatePublished - 2013

Bibliographical note

Funding Information:
This work has been partly funded by the Spanish MEC ( SAF 2009-13296-C02-01 ) and by the ICIC (Instituto Canario de Investigación del Cáncer).


  • Amaryllidaceae alkaloids
  • Antiplasmodial activity
  • Hippeastrine
  • Lycorenine


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