Phylobioactive hotspots in plant resources used to treat Chagas disease

Andrea Salm, Sandhya R. Krishnan, Marta Collu, Ombeline Danton, Matthias Hamburger, Marco Leonti, Giovanna Almanza, Jürg Gertsch

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Natural

Original languageEnglish
Article number102310
JournaliScience
Volume24
Issue number4
DOIs
StatePublished - 23 Apr 2021

Bibliographical note

Funding Information:
This study has received funding from the European Union's Seventh Framework Program for research, technological development, and demonstration under grant agreement no. 606895 . We would like to acknowledge the Guaraní, Ayoreo, Chiquitano, and Quechua informants who agreed to participate in the research and the members of the communities for their hospitality and interest. Rossy Chávez de Michel and Stephan Beck from the National Herbarium Bolivia (LPB) identified the herbarium specimens. We thank Yonny Flores, Alberto Giménez, and Efrain Salamanca (Universidad Mayor de San Andres) for technical assistance in the lab in Bolivia and for introducing the handling of T. cruzi. We acknowledge Matthias Rubin (University of Bern) for technical assistance in the lab and Peter Staub (Unica) for collecting DMM plant material and Laura Casu (Unica) for the production of extracts. We thank Peter Bütikofer (University of Bern) for sharing the T. brucei strain and giving advice on its cultivation.

Funding Information:
This study has received funding from the European Union's Seventh Framework Program for research, technological development, and demonstration under grant agreement no. 606895. We would like to acknowledge the Guaran?, Ayoreo, Chiquitano, and Quechua informants who agreed to participate in the research and the members of the communities for their hospitality and interest. Rossy Ch?vez de Michel and Stephan Beck from the National Herbarium Bolivia (LPB) identified the herbarium specimens. We thank Yonny Flores, Alberto Gim?nez, and Efrain Salamanca (Universidad Mayor de San Andres) for technical assistance in the lab in Bolivia and for introducing the handling of T. cruzi. We acknowledge Matthias Rubin (University of Bern) for technical assistance in the lab and Peter Staub (Unica) for collecting DMM plant material and Laura Casu (Unica) for the production of extracts. We thank Peter B?tikofer (University of Bern) for sharing the T. brucei strain and giving advice on its cultivation. A.S. S.R.K. and J.G. conceived and managed the project. A.S. carried out the fieldwork, analyzed, and curated data under the supervision of J.G. G.A. enabled the access to herbaria and contributed logistically to the fieldwork. M.C. and M.L. assembled the Dioscorides extract library. A.S. and S.R.K. carried out in vitro experiments with T. cruzi. A.S. and M.C. profiled plant extracts on different cells. O.D. performed the bioactivity-guided isolation of natural products under the supervision of M.H. A.S. and S.R.K. established the FACS parasite release assay. S.R.K. performed the SAR analysis with anthraquinones. M.C. and A.S. assembled the phylogenetic trees. A.S. and J.G. wrote the manuscript with input from all the authors. All the authors edited the manuscript to its final form. J.G. supervised the project. The authors declare that there is no conflict of interest. For the ethnopharmacological fieldwork, we worked to ensure gender balance in the recruitment of human subjects, to ensure ethnic or other types of diversity in the recruitment of human subjects, and to ensure that the study questionnaires were prepared in an inclusive way. The author list of this paper includes contributors from the location where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work.

Publisher Copyright:
© 2021 The Authors

Keywords

  • Bioactive Plant Product
  • Biological Sciences
  • Ethnobotany
  • Ethnopharmacology
  • Natural Product Chemistry
  • Plant Biology
  • Plants

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