Natural Pseudoguaianolides Prepared from Damsin

R. Villagomez, M. Quiroz, A. Tito, O. Sterner, G. R. Almanza

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Damsin (1) is a pseudoguaianolide sesquiterpene possessing potent biological activities, reported as a metabolite of several medicinal plants belonging to the genus Ambrosia together with related compounds. Starting from 1, which can be isolated in good amounts from Ambrosia arborescens, the five natural pseudoguaianolides ambrosin (2), isodamsin (3), 3α-hydroxydamsin (4), 3α-acetoxydamsin (5), and 11β,13-dihydrodamsin (8) were prepared by regio- and stereo-selective synthetic modifications.

Original languageEnglish
Pages (from-to)675-680
Number of pages6
JournalChemistry of Natural Compounds
Volume51
Issue number4
DOIs
StatePublished - 22 Jul 2015
Externally publishedYes

Bibliographical note

Funding Information:
The authors are grateful to the Swedish International Development Agency (SIDA) for support of this study, which is part of the Project “Research on Plant Biodiversity” developed between the University of San Andres (UMSA La Paz – Bolivia) and Lund University (Sweden).

Publisher Copyright:
© 2015 Springer Science+Business Media New York.

Keywords

  • ambrosanolides
  • damsin
  • derivatization
  • pseudoguaianolides
  • semi-synthesis
  • sesquiterpene lactones

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