Mulinane-type diterpenoids from Azorella compacta display antiplasmodial activity

Luis A. Loyola, Jorge Bórquez, Glauco Morales, Aurelio San-Martín, Jose Darias, Esther Ninoska Flores Quisbert Flores Quisbert, Alberto José Gimenez Turba

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45 Scopus citations

Abstract

Two mulinane-type diterpenoids were isolated from Azorella compacta; namely 20-hydroxymulin-11,13-dienyl acetate and 13,14-dihydroxymulin-11-en-20-oic acid. The structures were elucidated by analysis of their spectroscopic data. These compounds, as well as three previously isolated diterpenes, were evaluated as potential in vivo growth inhibitors of Plasmodium berghei NK 65 on infected mice at an intraperitoneal dose of 10 mg/kg/day. Sixty percent and forty-two percent growth inhibition were obtained with 17-acetoxymulin-11,13-dien-20-oic acid and 13, 14-dihydroxymulin-11-en-20-oic acid, respectively.

Original languageEnglish
Pages (from-to)1931-1935
Number of pages5
JournalPhytochemistry
Volume65
Issue number13
DOIs
StatePublished - Jul 2004

Bibliographical note

Funding Information:
This work was subsidized by the FONDECYT (Chile, Grant No. 1011068), Universidad de Antofagasta, CONICYT/CSIC (Grant 2002-3-073) and SECAB-CYTED (Grant C y T No. 1700 [K1-2002]). The work was developed as part of the Project X.5 from Subprogram X of CYTED. The field trip to Bolivia was supported by Agency Asdi/SAREC, Sweden.

Keywords

  • Azorella compacta
  • Diterpenoids
  • Plasmodium berghei
  • Umbelliferae

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