TY - JOUR
T1 - Metabolites from roots of Colubrina greggii var. Yucatanensis and Evaluation of their Antiprotozoan, Cytotoxic and antiproliferative activities
AU - Domínguez-Carmona, Dafne B.
AU - Escalante-Erosa, Fabiola
AU - García-Sosa, Karlina
AU - Ruiz-Pinell, Grace
AU - Gutierrez-Yapu, David
AU - Chan-Bacab, Manuel J.
AU - Moo-Puc, Rosa E.
AU - Veitch, Nigel C.
AU - Giménez-Turba, Alberto
AU - Peña-Rodríguez, Luis M.
PY - 2011
Y1 - 2011
N2 - Purification of the root extract of Colubrina greggii var. yucatanensis resulted in the isolation and identification of 3-O-acetyl ceanothic acid as a new natural ceanothane triterpene, together with the known metabolites ceanothic acid, cenothenic acid, betulinic acid, discarine B and chrysophanein. The natural products and the semisynthetic esters acetyl dimethyl ceanothate, dimethyl ceanothate and chrysophanein peracetate showed moderate to low leishmanicidal and trypanocidal activities. None of the metabolites showed cytotoxic or antiproliferative effects. The results also suggested that betulinic acid contributes to the antiplasmodial activity originally detected in the crude root extract of C. greggii var. yucatanensis.
AB - Purification of the root extract of Colubrina greggii var. yucatanensis resulted in the isolation and identification of 3-O-acetyl ceanothic acid as a new natural ceanothane triterpene, together with the known metabolites ceanothic acid, cenothenic acid, betulinic acid, discarine B and chrysophanein. The natural products and the semisynthetic esters acetyl dimethyl ceanothate, dimethyl ceanothate and chrysophanein peracetate showed moderate to low leishmanicidal and trypanocidal activities. None of the metabolites showed cytotoxic or antiproliferative effects. The results also suggested that betulinic acid contributes to the antiplasmodial activity originally detected in the crude root extract of C. greggii var. yucatanensis.
KW - Antiprotozoan
KW - Colubrina greggii var. yucatanensis
KW - Cytotoxic ceanothane
KW - Rhamnaceae
UR - http://www.scopus.com/inward/record.url?scp=79959771635&partnerID=8YFLogxK
U2 - 10.1590/S0103-50532011000700013
DO - 10.1590/S0103-50532011000700013
M3 - Artículo
AN - SCOPUS:79959771635
SN - 0103-5053
VL - 22
SP - 1279
EP - 1285
JO - Journal of the Brazilian Chemical Society
JF - Journal of the Brazilian Chemical Society
IS - 7
ER -