Metabolites from roots of Colubrina greggii var. Yucatanensis and Evaluation of their Antiprotozoan, Cytotoxic and antiproliferative activities

Dafne B. Domínguez-Carmona, Fabiola Escalante-Erosa, Karlina García-Sosa, Grace Ruiz-Pinell, David Gutierrez-Yapu, Manuel J. Chan-Bacab, Rosa E. Moo-Puc, Nigel C. Veitch, Alberto Giménez-Turba, Luis M. Peña-Rodríguez

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9 Scopus citations

Abstract

Purification of the root extract of Colubrina greggii var. yucatanensis resulted in the isolation and identification of 3-O-acetyl ceanothic acid as a new natural ceanothane triterpene, together with the known metabolites ceanothic acid, cenothenic acid, betulinic acid, discarine B and chrysophanein. The natural products and the semisynthetic esters acetyl dimethyl ceanothate, dimethyl ceanothate and chrysophanein peracetate showed moderate to low leishmanicidal and trypanocidal activities. None of the metabolites showed cytotoxic or antiproliferative effects. The results also suggested that betulinic acid contributes to the antiplasmodial activity originally detected in the crude root extract of C. greggii var. yucatanensis.

Original languageEnglish
Pages (from-to)1279-1285
Number of pages7
JournalJournal of the Brazilian Chemical Society
Volume22
Issue number7
DOIs
StatePublished - 2011

Keywords

  • Antiprotozoan
  • Colubrina greggii var. yucatanensis
  • Cytotoxic ceanothane
  • Rhamnaceae

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