Lower urinary tract dysfunction in chronic Chagas disease: clinical and urodynamic presentation

Elsa Bey, Maria Brigitte Paucara Condori, Olivier Gaget, Philippe Solano, Susana Revollo, Christian Saussine, Simone Frédérique Brenière

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Purpose: To describe and give an estimation of the prevalence of urinary disorders in chronic Chagas disease, since most clinical research has been centered on the description of the cardiac and digestive forms. Methods: To explore this topic, a cross-sectional study was conducted in 137 Bolivian adults of both sexes suffering from symptomatic chronic Chagas disease. All patients presenting confirmed chagasic cardiomyopathy, megacolon or both underwent a urologic symptom questionnaire, uroflowmetry, urinary tract ultrasonography and a creatinine assay. When urinary abnormality was detected, a complete urodynamic study was proposed including cystometry, pressure-flow studies and urethral pressure profile. Results: Out of all study patients, 35 (26%) had a Chagas cardiomyopathy, 81 (59%) a megacolon, and 21 (15%) a megacolon associated with cardiomyopathy. In all, 63% presented urinary disorders defined by IPSS > 7 and/or ICIQ SF > 1. Among them, 62% were incontinent, mainly by bladder overactivity, and 45% presented grade 2 or 3 renal insufficiency. Of 49 patients, the urodynamic study identified 34 patients with detrusor overactivity (69%), mostly in those with Chagas megacolon. Median bladder functional capacity, urethral closure pressure and bladder compliance had normal values. Moreover, 36% of these patients presented moderate hypocontractility, without significant post-void residual. Conclusions: This study evidenced lower urinary tract dysfunction in a majority of chronic chagasic patients; those presenting megacolon were more likely to suffer from urinary incontinence. These results strongly suggest including routine urological clinical investigation in chronic Chagas patients, as urinary incontinence due to overactive bladder is frequently observed in this population.

Original languageEnglish
Pages (from-to)1395-1402
Number of pages8
JournalWorld Journal of Urology
Volume37
Issue number7
DOIs
StatePublished - 1 Jul 2019

Bibliographical note

Funding Information:
We would like to thank Dr. Jacques Gardon, representative of the Institut de Recherche pour le Développement in Bolivia, and M. Reynaldo Choque Choque, journalist, for their assistance and implication in this work. We would also like to thank the firm Albyn Medical and M Pascal Marchetti for the high quality of the technical and logistic assistance provided in the difficult management of urodynamics in Bolivia.

Publisher Copyright:
© 2018, The Author(s).

Keywords

  • Bladder
  • Chronic Chagas disease
  • Lower urinary tract
  • Neurogenic bladder
  • Trypanosoma cruzi
  • Urodynamic

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