Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives

Oscar Rebollo, Esther del Olmo, Grace Ruiz, José L. López-Pérez, Alberto Giménez, Arturo San Feliciano

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A number of aminoalcohols, diamines and other related cycloanalogues of sphingosine have been synthesized and assayed in vitro against three Leishmania spp. and Trypanosoma cruzi. Most of the compounds were potent parasiticides, with IC50 values in the μM or lower range and potencies higher than those of pentamidine and benznidazol, the common therapeutic agents against these parasitoses.

Original languageEnglish
Pages (from-to)184-187
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number1
DOIs
StatePublished - 1 Jan 2008

Bibliographical note

Funding Information:
Financial support came from Spanish FIS-ISCIII (Grant No. PI060782). O.R. thanks the BS-USAL (Spain) for a doctoral fellowship. Collaborative work performed under the auspices of ‘ Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo (CYTED), Subprograma X ’.

Keywords

  • Aminoalcohols
  • Diamines
  • In vitro assays
  • Leishmania
  • SAR
  • Sphingosine
  • Synthesis
  • Trypanosoma

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