Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives

Oscar Rebollo; Esther del Olmo; Grace Ruiz; José L. López-Pérez; Alberto Giménez; Arturo San Feliciano

doi:10.1016/j.bmcl.2007.10.102

Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives

Oscar Rebollo, Esther del Olmo, Grace Ruiz, José L. López-Pérez, Alberto Giménez, Arturo San Feliciano

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A number of aminoalcohols, diamines and other related cycloanalogues of sphingosine have been synthesized and assayed in vitro against three Leishmania spp. and Trypanosoma cruzi. Most of the compounds were potent parasiticides, with IC₅₀ values in the μM or lower range and potencies higher than those of pentamidine and benznidazol, the common therapeutic agents against these parasitoses.

Original language	English
Pages (from-to)	184-187
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2007.10.102
State	Published - 1 Jan 2008

Bibliographical note

Funding Information:
Financial support came from Spanish FIS-ISCIII (Grant No. PI060782). O.R. thanks the BS-USAL (Spain) for a doctoral fellowship. Collaborative work performed under the auspices of ‘ Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo (CYTED), Subprograma X ’.

Keywords

Aminoalcohols
Diamines
In vitro assays
Leishmania
SAR
Sphingosine
Synthesis
Trypanosoma

Access to Document

10.1016/j.bmcl.2007.10.102

Cite this

@article{6d4c98c3547741f7bc8f5a9e570ab29d,

title = "Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives",

abstract = "A number of aminoalcohols, diamines and other related cycloanalogues of sphingosine have been synthesized and assayed in vitro against three Leishmania spp. and Trypanosoma cruzi. Most of the compounds were potent parasiticides, with IC50 values in the μM or lower range and potencies higher than those of pentamidine and benznidazol, the common therapeutic agents against these parasitoses.",

keywords = "Aminoalcohols, Diamines, In vitro assays, Leishmania, SAR, Sphingosine, Synthesis, Trypanosoma",

author = "Oscar Rebollo and {del Olmo}, Esther and Grace Ruiz and L{\'o}pez-P{\'e}rez, {Jos{\'e} L.} and Alberto Gim{\'e}nez and {San Feliciano}, Arturo",

note = "Funding Information: Financial support came from Spanish FIS-ISCIII (Grant No. PI060782). O.R. thanks the BS-USAL (Spain) for a doctoral fellowship. Collaborative work performed under the auspices of {\textquoteleft} Programa Iberoamericano de Ciencia y Tecnolog{\'i}a para el Desarrollo (CYTED), Subprograma X {\textquoteright}. ",

year = "2008",

month = jan,

day = "1",

doi = "10.1016/j.bmcl.2007.10.102",

language = "Ingl{\'e}s",

volume = "18",

pages = "184--187",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "1",

}

TY - JOUR

T1 - Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives

AU - Rebollo, Oscar

AU - del Olmo, Esther

AU - Ruiz, Grace

AU - López-Pérez, José L.

AU - Giménez, Alberto

AU - San Feliciano, Arturo

N1 - Funding Information: Financial support came from Spanish FIS-ISCIII (Grant No. PI060782). O.R. thanks the BS-USAL (Spain) for a doctoral fellowship. Collaborative work performed under the auspices of ‘ Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo (CYTED), Subprograma X ’.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - A number of aminoalcohols, diamines and other related cycloanalogues of sphingosine have been synthesized and assayed in vitro against three Leishmania spp. and Trypanosoma cruzi. Most of the compounds were potent parasiticides, with IC50 values in the μM or lower range and potencies higher than those of pentamidine and benznidazol, the common therapeutic agents against these parasitoses.

AB - A number of aminoalcohols, diamines and other related cycloanalogues of sphingosine have been synthesized and assayed in vitro against three Leishmania spp. and Trypanosoma cruzi. Most of the compounds were potent parasiticides, with IC50 values in the μM or lower range and potencies higher than those of pentamidine and benznidazol, the common therapeutic agents against these parasitoses.

KW - Aminoalcohols

KW - Diamines

KW - In vitro assays

KW - Leishmania

KW - SAR

KW - Sphingosine

KW - Synthesis

KW - Trypanosoma

UR - http://www.scopus.com/inward/record.url?scp=37549032505&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2007.10.102

DO - 10.1016/j.bmcl.2007.10.102

M3 - Artículo

C2 - 18024033

AN - SCOPUS:37549032505

SN - 0960-894X

VL - 18

SP - 184

EP - 187

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this