Leishmanicidal Activity and Immunomodulatory Effect of a Mixture of Lupenone and β-Caryophyllene Oxide

Glendy M. Polanco-Hernández, Alberto Giménez-Turba, Efraín Salamanca, Giulia Getti, Rajeev Rai, Karla Y. Acosta-Viana, Víctor Ermilo Arana-Argáez, Julio César Torres-Romero, Karla Guadalupe Fernández-Martín, Maira Rubí Segura-Campos, Rosa E. Moo-Puc, Luis M. Peña-Rodríguez

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Evaluation of the leishmanicidal activity of different mixtures of β-caryophyllene oxide and lupenone against Old and New World Leishmania spp. showed that both the pure β-caryophyllene oxide and the 1:4 mixture of lupenone and β-caryophyllene oxide are similarly active against promastigotes of L. amazonensis, L. braziliensis, L. mexicana, L. tropica, and L. aethiopica, with IC50 values ranging from 14 to 39.3 μg/ml, and reduce the infectivity of macrophages by L. mexicana and L. tropica. However, the 1:4 mixture of lupenone and β-caryophyllene oxide showed a better selectivity index than the pure sesquiterpene and increased production of NO, H2O2, and cytokines; these results suggest that the 1:4 mixture of terpenoids has both leishmanicidal activity and an immunomodulator effect, without affecting cell viability. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalRevista Brasileira de Farmacognosia
Volume31
Issue number2
DOIs
StatePublished - Apr 2021

Bibliographical note

Funding Information:
The authors wish to thank María Claudia Peña-González for technical assistance. GMPH gratefully acknowledge CONACYT (Consejo Nacional de Ciencia y Tecnología) for support through its “Becas Mixtas” Program to carry out research stays in Bolivia and the UK.

Publisher Copyright:
© 2021, Sociedade Brasileira de Farmacognosia.

Keywords

  • Antiparasitic
  • Immunomodulators
  • Leishmanicidal activity
  • Phytotherapy
  • Synergism

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