Leishmanicidal Activity and Immunomodulatory Effect of a Mixture of Lupenone and β-Caryophyllene Oxide

Glendy M. Polanco-Hernández; Alberto Giménez-Turba; Efraín Salamanca; Giulia Getti; Rajeev Rai; Karla Y. Acosta-Viana; Víctor Ermilo Arana-Argáez; Julio César Torres-Romero; Karla Guadalupe Fernández-Martín; Maira Rubí Segura-Campos; Rosa E. Moo-Puc; Luis M. Peña-Rodríguez

doi:10.1007/s43450-021-00143-8

Leishmanicidal Activity and Immunomodulatory Effect of a Mixture of Lupenone and β-Caryophyllene Oxide

Glendy M. Polanco-Hernández, Alberto Giménez-Turba, Efraín Salamanca, Giulia Getti, Rajeev Rai, Karla Y. Acosta-Viana, Víctor Ermilo Arana-Argáez, Julio César Torres-Romero, Karla Guadalupe Fernández-Martín, Maira Rubí Segura-Campos, Rosa E. Moo-Puc, Luis M. Peña-Rodríguez

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4 Scopus citations

Abstract

Evaluation of the leishmanicidal activity of different mixtures of β-caryophyllene oxide and lupenone against Old and New World Leishmania spp. showed that both the pure β-caryophyllene oxide and the 1:4 mixture of lupenone and β-caryophyllene oxide are similarly active against promastigotes of L. amazonensis, L. braziliensis, L. mexicana, L. tropica, and L. aethiopica, with IC₅₀ values ranging from 14 to 39.3 μg/ml, and reduce the infectivity of macrophages by L. mexicana and L. tropica. However, the 1:4 mixture of lupenone and β-caryophyllene oxide showed a better selectivity index than the pure sesquiterpene and increased production of NO, H₂O₂, and cytokines; these results suggest that the 1:4 mixture of terpenoids has both leishmanicidal activity and an immunomodulator effect, without affecting cell viability. Graphical abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	199-206
Number of pages	8
Journal	Revista Brasileira de Farmacognosia
Volume	31
Issue number	2
DOIs	https://doi.org/10.1007/s43450-021-00143-8
State	Published - Apr 2021

Bibliographical note

Funding Information:
The authors wish to thank María Claudia Peña-González for technical assistance. GMPH gratefully acknowledge CONACYT (Consejo Nacional de Ciencia y Tecnología) for support through its “Becas Mixtas” Program to carry out research stays in Bolivia and the UK.

Publisher Copyright:
© 2021, Sociedade Brasileira de Farmacognosia.

Keywords

Antiparasitic
Immunomodulators
Leishmanicidal activity
Phytotherapy
Synergism

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10.1007/s43450-021-00143-8

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Polanco-Hernández, G. M., Giménez-Turba, A., Salamanca, E., Getti, G., Rai, R., Acosta-Viana, K. Y., Arana-Argáez, V. E., Torres-Romero, J. C., Fernández-Martín, K. G., Segura-Campos, M. R., Moo-Puc, R. E., & Peña-Rodríguez, L. M. (2021). Leishmanicidal Activity and Immunomodulatory Effect of a Mixture of Lupenone and β-Caryophyllene Oxide. Revista Brasileira de Farmacognosia, 31(2), 199-206. https://doi.org/10.1007/s43450-021-00143-8

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title = "Leishmanicidal Activity and Immunomodulatory Effect of a Mixture of Lupenone and β-Caryophyllene Oxide",

abstract = "Evaluation of the leishmanicidal activity of different mixtures of β-caryophyllene oxide and lupenone against Old and New World Leishmania spp. showed that both the pure β-caryophyllene oxide and the 1:4 mixture of lupenone and β-caryophyllene oxide are similarly active against promastigotes of L. amazonensis, L. braziliensis, L. mexicana, L. tropica, and L. aethiopica, with IC50 values ranging from 14 to 39.3 μg/ml, and reduce the infectivity of macrophages by L. mexicana and L. tropica. However, the 1:4 mixture of lupenone and β-caryophyllene oxide showed a better selectivity index than the pure sesquiterpene and increased production of NO, H2O2, and cytokines; these results suggest that the 1:4 mixture of terpenoids has both leishmanicidal activity and an immunomodulator effect, without affecting cell viability. Graphical abstract: [Figure not available: see fulltext.]",

keywords = "Antiparasitic, Immunomodulators, Leishmanicidal activity, Phytotherapy, Synergism",

author = "Polanco-Hern{\'a}ndez, {Glendy M.} and Alberto Gim{\'e}nez-Turba and Efra{\'i}n Salamanca and Giulia Getti and Rajeev Rai and Acosta-Viana, {Karla Y.} and Arana-Arg{\'a}ez, {V{\'i}ctor Ermilo} and Torres-Romero, {Julio C{\'e}sar} and Fern{\'a}ndez-Mart{\'i}n, {Karla Guadalupe} and Segura-Campos, {Maira Rub{\'i}} and Moo-Puc, {Rosa E.} and Pe{\~n}a-Rodr{\'i}guez, {Luis M.}",

note = "Publisher Copyright: {\textcopyright} 2021, Sociedade Brasileira de Farmacognosia.",

year = "2021",

month = apr,

doi = "10.1007/s43450-021-00143-8",

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Polanco-Hernández, GM, Giménez-Turba, A , Salamanca, E, Getti, G, Rai, R, Acosta-Viana, KY, Arana-Argáez, VE, Torres-Romero, JC, Fernández-Martín, KG, Segura-Campos, MR, Moo-Puc, RE & Peña-Rodríguez, LM 2021, 'Leishmanicidal Activity and Immunomodulatory Effect of a Mixture of Lupenone and β-Caryophyllene Oxide', Revista Brasileira de Farmacognosia, vol. 31, no. 2, pp. 199-206. https://doi.org/10.1007/s43450-021-00143-8

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T1 - Leishmanicidal Activity and Immunomodulatory Effect of a Mixture of Lupenone and β-Caryophyllene Oxide

AU - Polanco-Hernández, Glendy M.

AU - Giménez-Turba, Alberto

AU - Salamanca, Efraín

AU - Getti, Giulia

AU - Rai, Rajeev

AU - Acosta-Viana, Karla Y.

AU - Arana-Argáez, Víctor Ermilo

AU - Torres-Romero, Julio César

AU - Fernández-Martín, Karla Guadalupe

AU - Segura-Campos, Maira Rubí

AU - Moo-Puc, Rosa E.

AU - Peña-Rodríguez, Luis M.

PY - 2021/4

Y1 - 2021/4

N2 - Evaluation of the leishmanicidal activity of different mixtures of β-caryophyllene oxide and lupenone against Old and New World Leishmania spp. showed that both the pure β-caryophyllene oxide and the 1:4 mixture of lupenone and β-caryophyllene oxide are similarly active against promastigotes of L. amazonensis, L. braziliensis, L. mexicana, L. tropica, and L. aethiopica, with IC50 values ranging from 14 to 39.3 μg/ml, and reduce the infectivity of macrophages by L. mexicana and L. tropica. However, the 1:4 mixture of lupenone and β-caryophyllene oxide showed a better selectivity index than the pure sesquiterpene and increased production of NO, H2O2, and cytokines; these results suggest that the 1:4 mixture of terpenoids has both leishmanicidal activity and an immunomodulator effect, without affecting cell viability. Graphical abstract: [Figure not available: see fulltext.]

AB - Evaluation of the leishmanicidal activity of different mixtures of β-caryophyllene oxide and lupenone against Old and New World Leishmania spp. showed that both the pure β-caryophyllene oxide and the 1:4 mixture of lupenone and β-caryophyllene oxide are similarly active against promastigotes of L. amazonensis, L. braziliensis, L. mexicana, L. tropica, and L. aethiopica, with IC50 values ranging from 14 to 39.3 μg/ml, and reduce the infectivity of macrophages by L. mexicana and L. tropica. However, the 1:4 mixture of lupenone and β-caryophyllene oxide showed a better selectivity index than the pure sesquiterpene and increased production of NO, H2O2, and cytokines; these results suggest that the 1:4 mixture of terpenoids has both leishmanicidal activity and an immunomodulator effect, without affecting cell viability. Graphical abstract: [Figure not available: see fulltext.]

KW - Antiparasitic

KW - Immunomodulators

KW - Leishmanicidal activity

KW - Phytotherapy

KW - Synergism

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U2 - 10.1007/s43450-021-00143-8

DO - 10.1007/s43450-021-00143-8

M3 - Artículo

AN - SCOPUS:85103895995

VL - 31

SP - 199

EP - 206

JO - Revista Brasileira de Farmacognosia

JF - Revista Brasileira de Farmacognosia

SN - 0102-695X

IS - 2

ER -

Leishmanicidal Activity and Immunomodulatory Effect of a Mixture of Lupenone and β-Caryophyllene Oxide

Abstract

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Keywords

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