Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance

Juan Camilo Chacón-Duque; Kaustubh Adhikari; Macarena Fuentes-Guajardo; Javier Mendoza-Revilla; Victor Acuña-Alonzo; Rodrigo Barquera; Mirsha Quinto-Sánchez; Jorge Gómez-Valdés; Paola Everardo Martínez; Hugo Villamil-Ramírez; Tábita Hünemeier; Virginia Ramallo; Caio C. Silva de Cerqueira; Malena Hurtado; Valeria Villegas; Vanessa Granja; Mercedes Villena; René Vásquez; Elena Llop; José R. Sandoval; Alberto A. Salazar-Granara; Maria Laura Parolin; Karla Sandoval; Rosenda I. Peñaloza-Espinosa; Hector Rangel-Villalobos; Cheryl A. Winkler; William Klitz; Claudio Bravi; Julio Molina; Daniel Corach; Ramiro Barrantes; Verónica Gomes; Carlos Resende; Leonor Gusmão; Antonio Amorim; Yali Xue; Jean Michel Dugoujon; Pedro Moral; Rolando González-José; Lavinia Schuler-Faccini; Francisco M. Salzano; Maria Cátira Bortolini; Samuel Canizales-Quinteros; Giovanni Poletti; Carla Gallo; Gabriel Bedoya; Francisco Rothhammer; David Balding; Garrett Hellenthal; Andrés Ruiz-Linares

doi:10.1038/s41467-018-07748-z

Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance

Juan Camilo Chacón-Duque, Kaustubh Adhikari, Macarena Fuentes-Guajardo, Javier Mendoza-Revilla, Victor Acuña-Alonzo, Rodrigo Barquera, Mirsha Quinto-Sánchez, Jorge Gómez-Valdés, Paola Everardo Martínez, Hugo Villamil-Ramírez, Tábita Hünemeier, Virginia Ramallo, Caio C. Silva de Cerqueira, Malena Hurtado, Valeria Villegas, Vanessa Granja, Mercedes Villena, René Vásquez, Elena Llop, José R. SandovalAlberto A. Salazar-Granara, Maria Laura Parolin, Karla Sandoval, Rosenda I. Peñaloza-Espinosa, Hector Rangel-Villalobos, Cheryl A. Winkler, William Klitz, Claudio Bravi, Julio Molina, Daniel Corach, Ramiro Barrantes, Verónica Gomes, Carlos Resende, Leonor Gusmão, Antonio Amorim, Yali Xue, Jean Michel Dugoujon, Pedro Moral, Rolando González-José, Lavinia Schuler-Faccini, Francisco M. Salzano, Maria Cátira Bortolini, Samuel Canizales-Quinteros, Giovanni Poletti, Carla Gallo, Gabriel Bedoya, Francisco Rothhammer, David Balding, Garrett Hellenthal, Andrés Ruiz-Linares

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Abstract

Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.

Original language	English
Article number	5388
Journal	Nature Communications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41467-018-07748-z
State	Published - 1 Dec 2018

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Publisher Copyright:
© 2018, The Author(s).

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Chacón-Duque, J. C., Adhikari, K., Fuentes-Guajardo, M., Mendoza-Revilla, J., Acuña-Alonzo, V., Barquera, R., Quinto-Sánchez, M., Gómez-Valdés, J., Everardo Martínez, P., Villamil-Ramírez, H., Hünemeier, T., Ramallo, V., Silva de Cerqueira, C. C., Hurtado, M., Villegas, V., Granja, V., Villena, M., Vásquez, R., Llop, E., ... Ruiz-Linares, A. (2018). Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance. Nature Communications, 9(1), Article 5388. https://doi.org/10.1038/s41467-018-07748-z

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title = "Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance",

abstract = "Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.",

author = "Chac{\'o}n-Duque, \{Juan Camilo\} and Kaustubh Adhikari and Macarena Fuentes-Guajardo and Javier Mendoza-Revilla and Victor Acu{\~n}a-Alonzo and Rodrigo Barquera and Mirsha Quinto-S{\'a}nchez and Jorge G{\'o}mez-Vald{\'e}s and \{Everardo Mart{\'i}nez\}, Paola and Hugo Villamil-Ram{\'i}rez and T{\'a}bita H{\"u}nemeier and Virginia Ramallo and \{Silva de Cerqueira\}, \{Caio C.\} and Malena Hurtado and Valeria Villegas and Vanessa Granja and Mercedes Villena and Ren{\'e} V{\'a}squez and Elena Llop and Sandoval, \{Jos{\'e} R.\} and Salazar-Granara, \{Alberto A.\} and Parolin, \{Maria Laura\} and Karla Sandoval and Pe{\~n}aloza-Espinosa, \{Rosenda I.\} and Hector Rangel-Villalobos and Winkler, \{Cheryl A.\} and William Klitz and Claudio Bravi and Julio Molina and Daniel Corach and Ramiro Barrantes and Ver{\'o}nica Gomes and Carlos Resende and Leonor Gusm{\~a}o and Antonio Amorim and Yali Xue and Dugoujon, \{Jean Michel\} and Pedro Moral and Rolando Gonz{\'a}lez-Jos{\'e} and Lavinia Schuler-Faccini and Salzano, \{Francisco M.\} and Bortolini, \{Maria C{\'a}tira\} and Samuel Canizales-Quinteros and Giovanni Poletti and Carla Gallo and Gabriel Bedoya and Francisco Rothhammer and David Balding and Garrett Hellenthal and Andr{\'e}s Ruiz-Linares",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",

year = "2018",

month = dec,

day = "1",

doi = "10.1038/s41467-018-07748-z",

language = "Ingl{\'e}s",

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journal = "Nature Communications",

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Chacón-Duque, JC, Adhikari, K, Fuentes-Guajardo, M, Mendoza-Revilla, J, Acuña-Alonzo, V, Barquera, R, Quinto-Sánchez, M, Gómez-Valdés, J, Everardo Martínez, P, Villamil-Ramírez, H, Hünemeier, T, Ramallo, V, Silva de Cerqueira, CC, Hurtado, M, Villegas, V, Granja, V, Villena, M, Vásquez, R, Llop, E, Sandoval, JR, Salazar-Granara, AA, Parolin, ML, Sandoval, K, Peñaloza-Espinosa, RI, Rangel-Villalobos, H, Winkler, CA, Klitz, W, Bravi, C, Molina, J, Corach, D, Barrantes, R, Gomes, V, Resende, C, Gusmão, L, Amorim, A, Xue, Y, Dugoujon, JM, Moral, P, González-José, R, Schuler-Faccini, L, Salzano, FM, Bortolini, MC, Canizales-Quinteros, S, Poletti, G, Gallo, C, Bedoya, G, Rothhammer, F, Balding, D, Hellenthal, G & Ruiz-Linares, A 2018, 'Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance', Nature Communications, vol. 9, no. 1, 5388. https://doi.org/10.1038/s41467-018-07748-z

TY - JOUR

T1 - Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance

AU - Chacón-Duque, Juan Camilo

AU - Adhikari, Kaustubh

AU - Fuentes-Guajardo, Macarena

AU - Mendoza-Revilla, Javier

AU - Acuña-Alonzo, Victor

AU - Barquera, Rodrigo

AU - Quinto-Sánchez, Mirsha

AU - Gómez-Valdés, Jorge

AU - Everardo Martínez, Paola

AU - Villamil-Ramírez, Hugo

AU - Hünemeier, Tábita

AU - Ramallo, Virginia

AU - Silva de Cerqueira, Caio C.

AU - Hurtado, Malena

AU - Villegas, Valeria

AU - Granja, Vanessa

AU - Villena, Mercedes

AU - Vásquez, René

AU - Llop, Elena

AU - Sandoval, José R.

AU - Salazar-Granara, Alberto A.

AU - Parolin, Maria Laura

AU - Sandoval, Karla

AU - Peñaloza-Espinosa, Rosenda I.

AU - Rangel-Villalobos, Hector

AU - Winkler, Cheryl A.

AU - Klitz, William

AU - Bravi, Claudio

AU - Molina, Julio

AU - Corach, Daniel

AU - Barrantes, Ramiro

AU - Gomes, Verónica

AU - Resende, Carlos

AU - Gusmão, Leonor

AU - Amorim, Antonio

AU - Xue, Yali

AU - Dugoujon, Jean Michel

AU - Moral, Pedro

AU - González-José, Rolando

AU - Schuler-Faccini, Lavinia

AU - Salzano, Francisco M.

AU - Bortolini, Maria Cátira

AU - Canizales-Quinteros, Samuel

AU - Poletti, Giovanni

AU - Gallo, Carla

AU - Bedoya, Gabriel

AU - Rothhammer, Francisco

AU - Balding, David

AU - Hellenthal, Garrett

AU - Ruiz-Linares, Andrés

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.

AB - Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.

UR - http://www.scopus.com/inward/record.url?scp=85058883000&partnerID=8YFLogxK

U2 - 10.1038/s41467-018-07748-z

DO - 10.1038/s41467-018-07748-z

M3 - Artículo

C2 - 30568240

AN - SCOPUS:85058883000

SN - 2041-1723

VL - 9

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 5388

ER -

Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance

Abstract

Bibliographical note

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