In a search for new inhibitors of RNA-directed DNA-polymerases kuehneromycin A (1) was isolated from fermentations of a Tasmanian Kuehneromyces species. Its structure was elucidated by spectroscopic methods. Kuehneromycin A (1) is a non-competitive inhibitor of avian myeloblastosis virus (Ki 200 μm) and moloney murine leukemia virus (Ki 40 μ) reverse transcriptases. The second compound, kuehneromycin B (2) is a strong inhibitor of platelet aggregation stimulated with different inducers. In addition, both compounds exhibit cytotoxic and antimicrobial activities.
|Number of pages||10|
|Journal||Zeitschrift fur Naturforschung - Section C Journal of Biosciences|
|State||Published - 1 Feb 1995|
Bibliographical noteFunding Information:
The financial support of the Deutsche Forschungsgemeinschaft is gratefully acknowledged. A. G. thanks the Alexander von Humboldt-Foundation for a scholarship. We thank Drs Stegmeier and Dörge (Boehringer Mannheim) and their staff for providing facilities to perform the aggregation assays with human blood. We are grateful to Dr. B. Steffan and Mrs. R. Fröde for NMR and MS experiments.
- Kuehneromyces sp