Isolement et synthese de l’espintanol, nouveau monoterpene antiparasitaire

R. Hocquemiller, D. Cortes, G. J. Arango, S. H. Myint, A. Cave, A. Angelo, Victoria Muñoz Ortiz, A. Fournet

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

The in vitro leishmanicidal and trypanocidal activities of a petroleum ether extract of Oxandra espintana have been investigated. Four aromatic monoterpenes were isolated, of which two are novel: espintanol [3a], responsible for the antiparasite activity, and 0-methylespintanol [4]. Espintanol was tested in vitro on 20 strains of Trypanosoma cruzi and 12 strains of Leishmania spp. Its structure was determined by spectroscopic methods and confirmed by its preparation starting from carvacrol.

Original languageEnglish
Pages (from-to)445-452
Number of pages8
JournalJournal of Natural Products
Volume54
Issue number2
DOIs
StatePublished - 1 Mar 1991
Externally publishedYes

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