In vitro antiplasmodial activity of sesquiterpene lactones from Ambrosia tenuifolia

V. Martino; V. Sülsen; D. Gutierrez Yappu; L. Laurella; C. Anesini; A. Gimenez Turba; L. Muschietti

doi:10.1155/2011/352938

In vitro antiplasmodial activity of sesquiterpene lactones from Ambrosia tenuifolia

V. Martino, V. Sülsen, D. Gutierrez Yappu, L. Laurella, C. Anesini, A. Gimenez Turba, L. Muschietti

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15 Scopus citations

Abstract

The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated. Peruvin was the most active compound on F32 strain of P. falciparum with a 50 inhibitory concentration value (IC50) of 0.3g/mL (1.1M) whereas psilostachyin showed activity on both strains (IC50 = 0.6 (2.1M) and 1.8g/mL (6.4M)). Fifty percent cytotoxic concentration (CC50) values (48h) were 6.8g/mL (24.3M) and 10.0g/mL (37.9M) for psilostachyin and peruvin, respectively.

Original language	English
Article number	352938
Journal	Evidence-based Complementary and Alternative Medicine
Volume	2011
DOIs	https://doi.org/10.1155/2011/352938
State	Published - 2011

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title = "In vitro antiplasmodial activity of sesquiterpene lactones from Ambrosia tenuifolia",

abstract = "The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated. Peruvin was the most active compound on F32 strain of P. falciparum with a 50 inhibitory concentration value (IC50) of 0.3g/mL (1.1M) whereas psilostachyin showed activity on both strains (IC50 = 0.6 (2.1M) and 1.8g/mL (6.4M)). Fifty percent cytotoxic concentration (CC50) values (48h) were 6.8g/mL (24.3M) and 10.0g/mL (37.9M) for psilostachyin and peruvin, respectively.",

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T1 - In vitro antiplasmodial activity of sesquiterpene lactones from Ambrosia tenuifolia

AU - Martino, V.

AU - Sülsen, V.

AU - Gutierrez Yappu, D.

AU - Laurella, L.

AU - Anesini, C.

AU - Gimenez Turba, A.

AU - Muschietti, L.

PY - 2011

Y1 - 2011

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AB - The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated. Peruvin was the most active compound on F32 strain of P. falciparum with a 50 inhibitory concentration value (IC50) of 0.3g/mL (1.1M) whereas psilostachyin showed activity on both strains (IC50 = 0.6 (2.1M) and 1.8g/mL (6.4M)). Fifty percent cytotoxic concentration (CC50) values (48h) were 6.8g/mL (24.3M) and 10.0g/mL (37.9M) for psilostachyin and peruvin, respectively.

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In vitro antiplasmodial activity of sesquiterpene lactones from Ambrosia tenuifolia

Abstract

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