In vitro antiplasmodial activity of sesquiterpene lactones from Ambrosia tenuifolia

V. Martino, V. Sülsen, D. Gutierrez Yappu, L. Laurella, C. Anesini, A. Gimenez Turba, L. Muschietti

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Abstract

The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated. Peruvin was the most active compound on F32 strain of P. falciparum with a 50 inhibitory concentration value (IC50) of 0.3g/mL (1.1M) whereas psilostachyin showed activity on both strains (IC50 = 0.6 (2.1M) and 1.8g/mL (6.4M)). Fifty percent cytotoxic concentration (CC50) values (48h) were 6.8g/mL (24.3M) and 10.0g/mL (37.9M) for psilostachyin and peruvin, respectively.

Original languageEnglish
Article number352938
JournalEvidence-based Complementary and Alternative Medicine
Volume2011
DOIs
StatePublished - 2011

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