Immune Response to Trypanosoma cruzi Shed Acute Phase Antigen in Children from an Endemic Area for Chagas′ Disease in Bolivia

Simone Frédérique Brenière, Nina Yaksic, Jenny Telleria, Marie France Bosseno, François Noireau, Patrick Wincker, Daniel Sanchez

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24 Scopus citations

Abstract

A field study of the immune response to the shed acute phase antigen (SAPA) of Trypanosoma cruzi was carried out in the locality of Mizque, Cochabamba department. Bolivia. Schoolchildren (266), with an average of 8.6 ± 3.6 years, were surveyed for parasitological and serological diagnosis, as well as antibodies directed against SAPA using the corresponding recombinant protein in ELISA. The antibodies against SAPA were shown in 82% of patients presenting positive serological diagnosis (IgG specific antibodies). The positive and negative predictive values were 0.88. Antibodies anti-SAPA were shown in 80.8% of the chagasic patients in the initial stage of the infection (positive IgM serology and/or positive buffy coat (BC) test) and in 81.4% of the patients in the indeterminate stage of the infection (positive IgG serology with negative BC and IgM tests). These results show that the anti-SAPA response is not only present during the initial stage of the infection (few months) but extends some years after infection.

Original languageEnglish
Pages (from-to)503-507
Number of pages5
JournalMemorias do Instituto Oswaldo Cruz
Volume92
Issue number4
DOIs
StatePublished - 1997

Keywords

  • Humoral response
  • Serological diagnosis
  • Shed acute-phase antigen
  • Trypanosoma cruzi

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