In a search for inhibitors of RNA-directed DNA polymerases a new isolactarane sesquiterpenoid, hyphodontal (1), was isolated from fermentations of a Canadian Hyphodontia, species. Its structure was elucidated by spectroscopic, methods. Hyphodontal strongly inhibits the growth of several yeasts and is a non-competitive inhibitor of avian myeloblastosis virus (K1 346 [formula omitted]) and Moloney murine leukemia virus (Ki 112 µM) reverse, transcriptases. In addition, cytotoxic and antifungal activities were, observed.
|Number of pages||10|
|Journal||Zeitschrift fur Naturforschung - Section C Journal of Biosciences|
|State||Published - Oct 1994|
Bibliographical noteFunding Information:
The financial support of the Deutsche Forschungsgemeinschaft is gratefully acknowledged. A. G. thanks the Alexander von Humboldt Foundation for a fellowship. We thank Prof. Dr. H. Anke and Prof. Dr. O. Sterner for providing several sesquiterpenoid dialdehydes for comparison.
- Hyphodontia sp
- Reverse Transcriptases