Hyphodontal, a New Antifungal Inhibitor of Reverse Transcriptases from Hyphodontia, sp. (Corticiaceae, Basidiomycetes)

Gerhard Erkel, Timm Anke, Robert Velten, Alberto José Gimenez Turba, Wolfgang Steglich

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

In a search for inhibitors of RNA-directed DNA polymerases a new isolactarane sesquiterpenoid, hyphodontal (1), was isolated from fermentations of a Canadian Hyphodontia, species. Its structure was elucidated by spectroscopic, methods. Hyphodontal strongly inhibits the growth of several yeasts and is a non-competitive inhibitor of avian myeloblastosis virus (K1 346 [formula omitted]) and Moloney murine leukemia virus (Ki 112 µM) reverse, transcriptases. In addition, cytotoxic and antifungal activities were, observed.

Original languageEnglish
Pages (from-to)561-570
Number of pages10
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume49
Issue number9-10
DOIs
StatePublished - Oct 1994
Externally publishedYes

Bibliographical note

Funding Information:
The financial support of the Deutsche Forschungsgemeinschaft is gratefully acknowledged. A. G. thanks the Alexander von Humboldt Foundation for a fellowship. We thank Prof. Dr. H. Anke and Prof. Dr. O. Sterner for providing several sesquiterpenoid dialdehydes for comparison.

Keywords

  • Basidiomycetes
  • Hyphodontia sp
  • Isolactaranes
  • Reverse Transcriptases
  • Sesquiterpenes

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