Evaluation of substituted phenalenone analogues as antiplasmodial agents

David Gutiérrez, Esther Ninoska Flores Quisbert Flores Quisbert, Teresa Abad-Grillo, Grant McNaughton-Smith

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


A set of derivatives encompassing structural modifications on the privileged phenalenone scaffold were assessed for their antiplasmodial activities against a strain of chloroquine sensitive Plasmodium falciparum F32. Two compounds exhibited considerable effects against the malaria parasite (IC50≤1μg/mL), one of which maintained the same level of activity in a chloroquine-resistant strain. This is the first record of antiplasmodial activity on this type of scaffold, providing a new structural motif as a new lead for antimalarial activity.

Original languageEnglish
Pages (from-to)456-458
Number of pages3
JournalExperimental Parasitology
Issue number2
StatePublished - Oct 2013

Bibliographical note

Funding Information:
This work was supported by MINECO ( SAF 2012-37344-C03-01 ). N. Flores and D. Gutierrez are grateful to MAEC-AECID and project X.5 “Búsqueda, Obtención y Evaluación de Nuevos Agentes Antiparasitarios” CYTED (Iberoamerican Program of Science and Technology for Development), Subprogram.


  • Antiplasmodial
  • P. falciparum
  • Substituted phenalenones


Dive into the research topics of 'Evaluation of substituted phenalenone analogues as antiplasmodial agents'. Together they form a unique fingerprint.

Cite this