Evaluation of a competitive antibody enzyme immunoassay for specific diagnosis of Chagas' disease

Washington R. Cuña, C. Rodriguez, F. Torrico, D. Afchain, M. Loyens, P. Desjeux

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5 Scopus citations

Abstract

A competitive enzyme immunoassay based on the use of a monoclonal antibody (MAb) specific for 'component 5' of Trypanosoma cruzi was evaluated. The antigenicity and immunogenicity of this component has been observed in natural and experimental infections. The studies were conducted in an area of Bolivia where mixed infections with Leishmania braziliensis are frequent and present a problem in the accurate diagnosis of T. cruzi infections. The specificity and sensitivity of this assay as compared to the indirect immunofluorescence and ELISA tests were demonstrated. The present test has proved to be more specific than the immunofluorescence and ELISA tests.

Original languageEnglish
Pages (from-to)357-359
Number of pages3
JournalJournal of Parasitology
Volume75
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

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