Enhancement of a TH1 immune response in amphotericin B-treated mucocutaneous leishmaniasis

Washington R. Cuna, Rianed Velasquez, Janeth Riva, Ingrid Guachalla, Celeste Rodríguez

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

In an attempt to investigate the effects of treatment of human leishmaniasis, the cytokines produced by peripheral blood mononuclear cells (PBMCs) of patients with cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL) under treatment with amphotericin B were determined during the active disease from cocultures of cells and Leishmania (Viannia) braziliensis antigens. PBMC of these patients exhibited a nonsignificant marginal increased production of TNF-α upon antigen stimulation. However, under the same antigenic stimulus, patients with active MCL presented higher IFN-γ production compared to patients with CL. This increased IFN-γ production was accompanied by a drastically augmented IL-12 synthesis from cells of MCL patients. The highlighted T cell responses could be relevant for sound control measures of protozoan infections with emphasis on the combined usage of immunoenhancing agents and antiprotozoal drugs.

Original languageEnglish
Article number96410
JournalJournal of Biomedicine and Biotechnology
Volume2007
DOIs
StatePublished - 2007

Fingerprint

Dive into the research topics of 'Enhancement of a TH1 immune response in amphotericin B-treated mucocutaneous leishmaniasis'. Together they form a unique fingerprint.

Cite this