TY - JOUR
T1 - Elevated arsenic exposure and efficient arsenic metabolism in indigenous women around Lake Poopó Bolivia
AU - De Loma, Jessica
AU - Tirado, Noemi
AU - Ascui, Franz
AU - Levi, Michael
AU - Vahter, Marie
AU - Broberg, Karin
AU - Gardon, Jacques
N1 - Publisher Copyright:
© 2018 The Authors
PY - 2019/3/20
Y1 - 2019/3/20
N2 - Elevated concentrations of inorganic arsenic, one of the most potent environmental toxicants and carcinogens, have been detected in well water around Lake Poopó Bolivia. This study aimed to assess human exposure to arsenic in villages around Lake Poopó and also to elucidate whether the metabolism and detoxification of arsenic in this population is as efficient as previously indicated in other Andean areas. We recruited 201 women from 10 villages around Lake Poopó. Arsenic exposure was determined as the sum concentration of arsenic metabolites (inorganic arsenic; monomethylarsonic acid, MMA; and dimethylarsinic acid, DMA) in urine (U-As), measured by HPLC-HG-ICP-MS. Efficiency of arsenic metabolism was assessed by the relative fractions of the urinary metabolites. The women had a wide variation in U-As (range 12–407 μg/L, median 65 μg/L) and a markedly efficient metabolism of arsenic with low %MMA (median 7.7%, range: 2.2–18%) and high %DMA (80%, range: 54–91%) in urine. In multivariable-adjusted linear regression models, ethnicity (Aymara-Quechua vs. Uru), body weight, fish consumption and tobacco smoking were associated with urinary arsenic metabolite fractions. On average, the Uru women had 2.5 lower % (percentage unit) iAs, 2.2 lower %MMA and 4.7 higher %DMA compared with the Aymara-Quechua women. Our study identified several factors that may predict these women's arsenic methylation capacity, particularly ethnicity. Further studies should focus on mechanisms underlying these differences in arsenic metabolism efficiency, and its importance for the risk of arsenic-related health effects.
AB - Elevated concentrations of inorganic arsenic, one of the most potent environmental toxicants and carcinogens, have been detected in well water around Lake Poopó Bolivia. This study aimed to assess human exposure to arsenic in villages around Lake Poopó and also to elucidate whether the metabolism and detoxification of arsenic in this population is as efficient as previously indicated in other Andean areas. We recruited 201 women from 10 villages around Lake Poopó. Arsenic exposure was determined as the sum concentration of arsenic metabolites (inorganic arsenic; monomethylarsonic acid, MMA; and dimethylarsinic acid, DMA) in urine (U-As), measured by HPLC-HG-ICP-MS. Efficiency of arsenic metabolism was assessed by the relative fractions of the urinary metabolites. The women had a wide variation in U-As (range 12–407 μg/L, median 65 μg/L) and a markedly efficient metabolism of arsenic with low %MMA (median 7.7%, range: 2.2–18%) and high %DMA (80%, range: 54–91%) in urine. In multivariable-adjusted linear regression models, ethnicity (Aymara-Quechua vs. Uru), body weight, fish consumption and tobacco smoking were associated with urinary arsenic metabolite fractions. On average, the Uru women had 2.5 lower % (percentage unit) iAs, 2.2 lower %MMA and 4.7 higher %DMA compared with the Aymara-Quechua women. Our study identified several factors that may predict these women's arsenic methylation capacity, particularly ethnicity. Further studies should focus on mechanisms underlying these differences in arsenic metabolism efficiency, and its importance for the risk of arsenic-related health effects.
KW - Arsenic
KW - Aymara
KW - Bolivia
KW - Methylation
KW - Quechua
KW - Uru
UR - http://www.scopus.com/inward/record.url?scp=85057734960&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2018.11.473
DO - 10.1016/j.scitotenv.2018.11.473
M3 - Artículo
C2 - 30537579
AN - SCOPUS:85057734960
SN - 0048-9697
VL - 657
SP - 179
EP - 186
JO - Science of the Total Environment
JF - Science of the Total Environment
ER -